ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.

ACE2 deficiency enhances angiotensin II-mediated aortic profilin-1 expression, inflammation and peroxynitrite production.

Inflammation and oxidative stress play a crucial role in angiotensin (Ang) II-mediated vascular injury. Angiotensin-converting enzyme 2 (ACE2) has recently been identified as a specific Ang II-degrading enzyme but its role in vascular biology remains elusive. We hypothesized that loss of ACE2 would...

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Bibliographic Details
Main Authors: Hai-Yan Jin, Bei Song, Gavin Y Oudit, Sandra T Davidge, Hui-Min Yu, Yan-Yan Jiang, Ping-Jin Gao, Ding-Liang Zhu, Guang Ning, Zamaneh Kassiri, Josef M Penninger, Jiu-Chang Zhong
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3367919?pdf=render

Internet

http://europepmc.org/articles/PMC3367919?pdf=render

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