Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels.

Overexpression of Glutamate Decarboxylase in Mesenchymal Stem Cells Enhances Their Immunosuppressive Properties and Increases GABA and Nitric Oxide Levels.

The neurotransmitter GABA has been recently identified as a potent immunosuppressive agent that targets both innate and adaptive immune systems and prevents disease progression of several autoimmunity models. Mesenchymal stem cells (MSCs) are self-renewing progenitor cells that differentiate into va...

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Bibliographic Details
Main Authors: Mariana Urrutia, Sebastián Fernández, Marisol González, Rodrigo Vilches, Pablo Rojas, Manuel Vásquez, Mónica Kurte, Ana María Vega-Letter, Flavio Carrión, Fernando Figueroa, Patricio Rojas, Carlos Irarrázabal, Rodrigo A Fuentealba
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5035029?pdf=render

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