Simvastatin Attenuates Neurogenetic Damage and Improves Neurocongnitive Deficits Induced by Isoflurane in Neonatal Rats

Simvastatin Attenuates Neurogenetic Damage and Improves Neurocongnitive Deficits Induced by Isoflurane in Neonatal Rats

Background/Aims: Isoflurane inhibited neurogenesis and induced subsequent neurocognitive deficits in developing brain. Simvastatin exerts neuroprotection in a wide range of brain injury models. In the present study, we investigated whether simvastatin could attenuate neurogenetic inhibition and cogn...

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Bibliographic Details
Main Authors: Ning Wang, Yang Lu, Kui Wang, Wei-song Li, Pan Lu, Shan Lei, Rong Li, Hong Zhang, Juan Zheng, Hai-xia Lu, Xin-lin Chen, Yong Liu, Peng-bo Zhang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2018-03-01
Series:Cellular Physiology and Biochemistry
Subjects:
Isoflurane
Neural stem cells
Akt
GSK-3β
Caspase-3
Simvastatin
Online Access:https://www.karger.com/Article/FullText/488630

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