Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs

Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.

Bibliographic Details
Main Authors: Askar Yimit, Ogun Adebali, Aziz Sancar, Yuchao Jiang
Format: Article
Language:English
Published: Nature Publishing Group 2019-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-08290-2
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spelling doaj-e8c9077bcabd4f6dbd5440dc994c09772021-05-11T11:48:10ZengNature Publishing GroupNature Communications2041-17232019-01-0110111110.1038/s41467-019-08290-2Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organsAskar Yimit0Ogun Adebali1Aziz Sancar2Yuchao Jiang3Department of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel HillMolecular Biology, Genetics and Bioengineering Program, Faculty of Engineering and Natural Sciences, Sabanci UniversityDepartment of Biochemistry and Biophysics, School of Medicine, University of North Carolina at Chapel HillLineberger Comprehensive Cancer Center, University of North Carolina at Chapel HillCisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.https://doi.org/10.1038/s41467-019-08290-2
collection DOAJ
language English
format Article
sources DOAJ
author Askar Yimit
Ogun Adebali
Aziz Sancar
Yuchao Jiang
spellingShingle Askar Yimit
Ogun Adebali
Aziz Sancar
Yuchao Jiang
Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
Nature Communications
author_facet Askar Yimit
Ogun Adebali
Aziz Sancar
Yuchao Jiang
author_sort Askar Yimit
title Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_short Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_full Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_fullStr Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_full_unstemmed Differential damage and repair of DNA-adducts induced by anti-cancer drug cisplatin across mouse organs
title_sort differential damage and repair of dna-adducts induced by anti-cancer drug cisplatin across mouse organs
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2019-01-01
description Cisplatin, a platinum chemotherapeutic agent, is widely used to treat several cancers. Here Yimit et al. revert to genome-wide approaches to map and analyze cisplatin damage formation and excision repair with single nucleotide resolution across different mice organs following platinum treatment.
url https://doi.org/10.1038/s41467-019-08290-2
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AT ogunadebali differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans
AT azizsancar differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans
AT yuchaojiang differentialdamageandrepairofdnaadductsinducedbyanticancerdrugcisplatinacrossmouseorgans
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