Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an urgent need for identification of biomarkers i...
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Frontiers Media S.A.
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2020.00445/full |
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doaj-e89c9cf7022f44199ba6823b84219d962020-11-25T02:52:09ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2020-04-011010.3389/fonc.2020.00445502055Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical EvaluationLuca Ferrari0Michele Carugno1Michele Carugno2Carolina Mensi3Angela Cecilia Pesatori4Angela Cecilia Pesatori5EPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyEpidemiology Unit, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyEpidemiology Unit, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyEPIGET LAB, Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, ItalyEpidemiology Unit, Department of Preventive Medicine, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyMalignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an urgent need for identification of biomarkers in easily accessible samples (such as blood) for early diagnosis of MPM. In the last 10 years, epigenetic markers, such as DNA methylation and microRNAs (miRNAs), have gained popularity as possible early diagnostic and prognostic biomarkers in cancer research. The aim of this review is to provide a critical analysis of the current evidences on circulating epigenetic biomarkers for MPM and on their translational potential to the clinical practice for early diagnosis and for prognosis.https://www.frontiersin.org/article/10.3389/fonc.2020.00445/fullmicroRNADNA methylationepigeneticscirculating biomarkersmesothelioma |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Luca Ferrari Michele Carugno Michele Carugno Carolina Mensi Angela Cecilia Pesatori Angela Cecilia Pesatori |
| spellingShingle |
Luca Ferrari Michele Carugno Michele Carugno Carolina Mensi Angela Cecilia Pesatori Angela Cecilia Pesatori Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation Frontiers in Oncology microRNA DNA methylation epigenetics circulating biomarkers mesothelioma |
| author_facet |
Luca Ferrari Michele Carugno Michele Carugno Carolina Mensi Angela Cecilia Pesatori Angela Cecilia Pesatori |
| author_sort |
Luca Ferrari |
| title |
Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation |
| title_short |
Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation |
| title_full |
Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation |
| title_fullStr |
Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation |
| title_full_unstemmed |
Circulating Epigenetic Biomarkers in Malignant Pleural Mesothelioma: State of the Art and critical Evaluation |
| title_sort |
circulating epigenetic biomarkers in malignant pleural mesothelioma: state of the art and critical evaluation |
| publisher |
Frontiers Media S.A. |
| series |
Frontiers in Oncology |
| issn |
2234-943X |
| publishDate |
2020-04-01 |
| description |
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an urgent need for identification of biomarkers in easily accessible samples (such as blood) for early diagnosis of MPM. In the last 10 years, epigenetic markers, such as DNA methylation and microRNAs (miRNAs), have gained popularity as possible early diagnostic and prognostic biomarkers in cancer research. The aim of this review is to provide a critical analysis of the current evidences on circulating epigenetic biomarkers for MPM and on their translational potential to the clinical practice for early diagnosis and for prognosis. |
| topic |
microRNA DNA methylation epigenetics circulating biomarkers mesothelioma |
| url |
https://www.frontiersin.org/article/10.3389/fonc.2020.00445/full |
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