Synthesis of Novel 2-(Substituted amino)alkylthiopyrimidin-4(3H)-ones as Potential Antimicrobial Agents

Synthesis of Novel 2-(Substituted amino)alkylthiopyrimidin-4(3H)-ones as Potential Antimicrobial Agents

5-Alkyl-6-(substituted benzyl)-2-thiouracils 3a,c were reacted with (2-chloroethyl) diethylamine hydrochloride to afford the corresponding 2-(2-diethylamino)ethylthiopyrimidin- 4(3H)-ones 4a,b. Reaction of 3a–c with N-(2-chloroethyl)pyrrolidine hydrochloride and/or N-(2-chloroethyl)piperidine hydroc...

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Bibliographic Details
Main Authors: Mohamed I. Attia, Ali A. El-Emam, Abdulghafoor A. Al-Turkistani, Amany L. Kansoh, Nasser R. El-Brollosy
Format: Article
Language:English
Published: MDPI AG 2013-12-01
Series:Molecules
Subjects:
2-thiouracils
pyrimidin-4(3H)-ones
alkylation
antibacterial activity
anti-fungal activity
Online Access:http://www.mdpi.com/1420-3049/19/1/279

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