Understanding the Hysteresis Loop Conundrum in Pharmacokinetic / Pharmacodynamic Relationships

Hysteresis loops are phenomena that sometimes are encountered in the analysis of pharmacokinetic and pharmacodynamic relationships spanning from pre-clinical to clinical studies. When hysteresis occurs it provides insight into the complexity of drug action and disposition that can be encountered. H...

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Bibliographic Details
Main Authors: Christopher Louizos, Jaime A Yáñez, M Laird Forrest, Neal M Davies
Format: Article
Language:English
Published: Canadian Society for Pharmaceutical Sciences 2014-03-01
Series:Journal of Pharmacy & Pharmaceutical Sciences
Online Access:https://journals.library.ualberta.ca/jpps/index.php/JPPS/article/view/21028