TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation

TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation

Autophagy flux deficiency is closely related to the development of hepatic steatosis. Transcription factor E3 (TFE3) is reported to be a crucial gene that regulates autophagy flux and lysosome function. Therefore, we investigated the role of TFE3 in a cell model of hepatic steatosis. We constructed...

Full description

Bibliographic Details
Main Authors:	Jie Xiong, Kezhou Wang, Jiangping He, Guangya Zhang, Dandan Zhang, Fengling Chen
Format:	Article
Language:	English
Published:	MDPI AG 2016-03-01
Series:	International Journal of Molecular Sciences
Subjects:	TFE3 hepatic steatosis autophagy PGC1α β-oxidation
Online Access:	http://www.mdpi.com/1422-0067/17/3/387

Similar Items

Emerging roles and regulation of MiT/TFE transcriptional factors
by: Min Yang, et al.
Published: (2018-06-01)

A stress response p38 MAP kinase inhibitor SB202190 promoted TFEB/TFE3-dependent autophagy and lysosomal biogenesis independent of p38
by: Chuanbin Yang, et al.
Published: (2020-05-01)

Autophagy in Hepatic Steatosis: A Structured Review
by: Vitor de Miranda Ramos, et al.
Published: (2021-04-01)

Nuclear TFE3 expression is a diagnostic marker for Desmoid-type fibromatosis
by: Luting Zhou, et al.
Published: (2019-05-01)

3,4‐Dimethoxychalcone induces autophagy through activation of the transcription factors TFE3 and TFEB
by: Guo Chen, et al.
Published: (2019-11-01)

Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1‐dependent TFEB/TFE3 regulation
by: Reini E N van der Welle, et al.
Published: (2021-05-01)

TFE3-Expressing Perivascular Epithelioid Cell Tumor of the Breast
by: Hyunjin Kim, et al.
Published: (2019-01-01)

Kidney carcinoma associated with Xp11.2 translocation / TFE3 (ASPL-TFE3) gene fusion
by: Paulo G. O. Salles, et al.
Published: (2005-06-01)

Mitochondrial Energy-Regulating Effect of Atractyloside Inhibits Hepatocellular Steatosis Through the Activation of Autophagy
by: Pengfei Zhang, et al.
Published: (2020-09-01)

Defective Autophagy in T Cells Impairs the Development of Diet-Induced Hepatic Steatosis and Atherosclerosis
by: Jacob Amersfoort, et al.
Published: (2018-12-01)

Iridoids of Valeriana fauriei contribute to alleviating hepatic steatosis in obese mice by lipophagy
by: Da-Hye Lee, et al.
Published: (2020-05-01)

Rhodiola crenulata root extract ameliorates fructose-induced hepatic steatosis in rats: Association with activating autophagy
by: Chunlin Yuan, et al.
Published: (2020-05-01)

Metformin Alleviates Hepatic Steatosis and Insulin Resistance in a Mouse Model of High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease by Promoting Transcription Factor EB-Dependent Autophagy
by: Dan Zhang, et al.
Published: (2021-07-01)

Serotonin induced hepatic steatosis is associated with modulation of autophagy and notch signaling pathway
by: Suryakant Niture, et al.
Published: (2018-11-01)

Archaeal TFEα/β is a hybrid of TFIIE and the RNA polymerase III subcomplex hRPC62/39
by: Fabian Blombach, et al.
Published: (2015-06-01)

Folliculin: A Regulator of Transcription Through AMPK and mTOR Signaling Pathways
by: Josué M. J. Ramirez Reyes, et al.
Published: (2021-04-01)

Hepatic autophagy fluctuates during the development of non-alcoholic fatty liver disease
by: Hao Ding, et al.
Published: (2020-09-01)

Lipophagy and Alcohol-Induced Fatty Liver
by: Li Yang, et al.
Published: (2019-05-01)

The Expanding Role of Mitochondria, Autophagy and Lipophagy in Steroidogenesis
by: Geetika Bassi, et al.
Published: (2021-07-01)

MiT/TFE Family of Transcription Factors: An Evolutionary Perspective
by: Martina La Spina, et al.
Published: (2021-01-01)

Herbal Extracts and Natural Products in Alleviating Non-alcoholic Fatty Liver Disease via Activating Autophagy
by: Li Zhang, et al.
Published: (2018-12-01)

The transcription factors TFE3 and TFEB amplify p53 dependent transcriptional programs in response to DNA damage
by: Owen A Brady, et al.
Published: (2018-12-01)

CD36 plays a negative role in the regulation of lipophagy in hepatocytes through an AMPK-dependent pathway[S]
by: Yun Li, et al.
Published: (2019-04-01)

Potential of Telomerase in Age-Related Macular Degeneration—Involvement of Senescence, DNA Damage Response and Autophagy and a Key Role of PGC-1α
by: Janusz Blasiak, et al.
Published: (2021-07-01)

Fermented mulberry (Morus alba) leaves suppress high fat diet-induced hepatic steatosis through amelioration of the inflammatory response and autophagy pathway
by: Mi Rim Lee, et al.
Published: (2020-09-01)

Effect of Adrenergic Agonists on High-Fat Diet-Induced Hepatic Steatosis in Mice
by: Yukiomi Nakade, et al.
Published: (2020-12-01)

Study of Treatment Outcome in Adults with TFE-Related RCC
by: Ajaykumar Chandrabhan Singh, et al.
Published: (2021-04-01)

Effects of High-Fat Diet on Steatosis, Endoplasmic Reticulum Stress and Autophagy in Liver of Tilapia (Oreochromis niloticus)
by: Rui Jia, et al.
Published: (2020-05-01)

Supplementation of <i>Abelmoschus manihot</i> Ameliorates Diabetic Nephropathy and Hepatic Steatosis by Activating Autophagy in Mice
by: Hwajin Kim, et al.
Published: (2018-11-01)

Autophagy: a new target for nonalcoholic fatty liver disease therapy
by: Mao YQ, et al.
Published: (2016-03-01)

Long Non-Coding RNA LINC02747 Promotes the Proliferation of Clear Cell Renal Cell Carcinoma by Inhibiting miR-608 and Activating TFE3
by: Xiang Ju, et al.
Published: (2020-12-01)

IDENTIFICATION OF HUMAN PGC-1α-b ISOFORMS USING A NOVEL PGC-1α-b SPECIFIC ANTIBODY
by: Hedrick, Shannon
Published: (2013)

Targeting TFE3 Protects Against Lysosomal Malfunction-Induced Pyroptosis in Random Skin Flaps via ROS Elimination
by: Jiafeng Li, et al.
Published: (2021-04-01)

Renal cell carcinoma with MiTF/TFE3 translocation in children: Report of a case at the stage of lymph node involvement
by: Boubacar Fall, et al.
Published: (2011-01-01)

Metformin‐induced autophagy and irisin improves INS‐1 cell function and survival in high‐glucose environment via AMPK/SIRT1/PGC‐1α signal pathway
by: Qingxue Li, et al.
Published: (2019-05-01)

Estudo da expressão das proteínas TFE3 e receptor de insulina nos hepatoblastomas a partir dos achados de expressão gênica
by: Renée Zon Filippi
Published: (2011)

Estudo da expressão das proteínas TFE3 e receptor de insulina nos hepatoblastomas a partir dos achados de expressão gênica
by: Filippi, Renée Zon
Published: (2011)

The incidence of renal cell carcinoma associated with Xp11.2 translocation/TFE3 gene fusion in Saudi adult patients with renal cancer: a retrospective tissue microarray analysis
by: Jaudah Al-Maghrabi, et al.
Published: (2019-01-01)

Alveolar soft part sarcoma of the bladder with ASPSCR1-TFE3 gene fusion as a secondary malignancy
by: Daniel S. Rhee, et al.
Published: (2017-12-01)

Hengshun Aromatic Vinegar Improves Glycolipid Metabolism in Type 2 Diabetes Mellitus via Regulating PGC-1α/PGC-1β Pathway
by: Guoquan Li, et al.
Published: (2021-04-01)