TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation

TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation

Autophagy flux deficiency is closely related to the development of hepatic steatosis. Transcription factor E3 (TFE3) is reported to be a crucial gene that regulates autophagy flux and lysosome function. Therefore, we investigated the role of TFE3 in a cell model of hepatic steatosis. We constructed...

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Bibliographic Details
Main Authors: Jie Xiong, Kezhou Wang, Jiangping He, Guangya Zhang, Dandan Zhang, Fengling Chen
Format: Article
Language:English
Published: MDPI AG 2016-03-01
Series:International Journal of Molecular Sciences
Subjects:
TFE3
hepatic steatosis
autophagy
PGC1α
β-oxidation
Online Access:http://www.mdpi.com/1422-0067/17/3/387

Internet

http://www.mdpi.com/1422-0067/17/3/387

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