Discovery of Flavonoids from Scutellaria baicalensis with Inhibitory Activity Against PCSK 9 Expression: Isolation, Synthesis and Their Biological Evaluation

Discovery of Flavonoids from Scutellaria baicalensis with Inhibitory Activity Against PCSK 9 Expression: Isolation, Synthesis and Their Biological Evaluation

Nine flavonoids were isolated and identified from a chloroform-soluble fraction of the roots of Scutellaria baicalensis through a bioactivity-guided fractionation using a proprotein convertase subtilisin/kexin type 9 (PCSK9) monitoring assay in HepG2 cells. All structures were established by interpr...

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Bibliographic Details
Main Authors: Piseth Nhoek, Hee-Sung Chae, Jagadeesh Nagarajappa Masagalli, Karabasappa Mailar, Pisey Pel, Young-Mi Kim, Won Jun Choi, Young-Won Chin
Format: Article
Language:English
Published: MDPI AG 2018-02-01
Series:Molecules
Subjects:
Scutellaria baicalensis
flavonoid
PCSK9
SREBP-1
low density lipoprotein receptor
Online Access:http://www.mdpi.com/1420-3049/23/2/504

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