A “Lymphocyte MicroRNA Signature” as Predictive Biomarker of Immunotherapy Response and Plasma PD-1/PD-L1 Expression Levels in Patients with Metastatic Renal Cell Carcinoma: Pointing towards Epigenetic Reprogramming

A “Lymphocyte MicroRNA Signature” as Predictive Biomarker of Immunotherapy Response and Plasma PD-1/PD-L1 Expression Levels in Patients with Metastatic Renal Cell Carcinoma: Pointing towards Epigenetic Reprogramming

Introduction of checkpoint inhibitors resulted in durable responses and improvements in overall survival in advanced RCC patients, but the treatment efficacy is widely variable, and a considerable number of patients are resistant to PD-1/PD-L1 inhibition. This variability of clinical response makes...

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Bibliographic Details
Main Authors: Lorena Incorvaia, Daniele Fanale, Giuseppe Badalamenti, Chiara Brando, Marco Bono, Ida De De Luca, Laura Algeri, Annalisa Bonasera, Lidia Rita Corsini, Salvatore Scurria, Juan Lucio Iovanna, Antonio Russo, Viviana Bazan
Format: Article
Language:English
Published: MDPI AG 2020-11-01
Series:Cancers
Subjects:
microRNA
miRNA
PD-1
PD-L1
predictive biomarkers
renal cell carcinoma
Online Access:https://www.mdpi.com/2072-6694/12/11/3396

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https://www.mdpi.com/2072-6694/12/11/3396

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