Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

Histamine 2 Receptor Agonism and Histamine 4 Receptor Antagonism Ameliorate Inflammation in a Model of Psoriasis

Psoriasis is a chronic inflammatory skin disorder characterized by hyperproliferative keratinocytes and immune cell infiltration into the skin, often accompanied by itch. Histamine, acting via histamine 1–4 receptors, is known to modulate immune responses in the skin and to induce itch. The aim of t...

Full description

Bibliographic Details
Main Authors:	Kristine Rossbach, Katharina Wahle, Gustav Bruer, Ralph Brehm, Marion Langeheine, Kristina Rode, Katrin Schaper-Gerhardt, Ralf Gutzmer, Thomas Werfel, Manfred Kietzmann, Wolfgang Bäumer
Format:	Article
Language:	English
Published:	Society for Publication of Acta Dermato-Venereologica 2020-12-01
Series:	Acta Dermato-Venereologica
Subjects:	histamine psoriasis itch h2 receptor h4 receptor
Online Access:	https://www.medicaljournals.se/acta/content/html/10.2340/00015555-3674

Similar Items

TRPV1 and TRPA1 Channels Are Both Involved Downstream of Histamine-Induced Itch
by: Jenny Wilzopolski, et al.
Published: (2021-08-01)

Histamina, receptores de histamina e anti-histamínicos: novos conceitos Histamine, histamine receptors and antihistamines: new concepts
by: Paulo Ricardo Criado, et al.
Published: (2010-04-01)

The Role of Histamine H1 and H4 Receptors in Atopic Dermatitis: From Basic Research to Clinical Study
by: Yusuke Ohsawa, et al.
Published: (2014-01-01)

Suppression of IFN-γ Production in Murine Splenocytes by Histamine Receptor Antagonists
by: Miho Kamei, et al.
Published: (2018-12-01)

The Target Residence Time of Antihistamines Determines Their Antagonism of the G Protein-Coupled Histamine H1 Receptor
by: Reggie Bosma, et al.
Published: (2017-09-01)

Histamine and Delirium: Current Opinion
by: Paul L. Chazot, et al.
Published: (2019-04-01)

The Effects of Histamine H3 Receptors on Contractile Responses on Rat Gastric Fundus
by: Aşkın Hekimoğlu, et al.
Published: (2006-01-01)

Histamine H3 receptor: A novel therapeutic target in alcohol dependence?
by: Pertti ePanula, et al.
Published: (2012-05-01)

Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease
by: Danxia Qin, et al.
Published: (2019-05-01)

Discovery of Potential, Dual-Active Histamine H<sub>3</sub> Receptor Ligands with Combined Antioxidant Properties
by: Kamil J. Kuder, et al.
Published: (2021-04-01)

Commentary: Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications
by: Abdelhakim Salem, et al.
Published: (2020-06-01)

Histamine upregulates the expression of histamine receptors and increases the neuroprotective effect of astrocytes
by: Jiawen Xu, et al.
Published: (2018-02-01)

Histamine <i>N</i>-Methyltransferase in the Brain
by: Takeo Yoshikawa, et al.
Published: (2019-02-01)

The Role of Histamine and Histamine Receptors in Mast Cell-Mediated Allergy and Inflammation: The Hunt for New Therapeutic Targets
by: Elden Berla Thangam, et al.
Published: (2018-08-01)

Anticonvulsant effects of isomeric nonimidazole histamine H3 receptor antagonists
by: Sadek B, et al.
Published: (2016-11-01)

Non-imidazole-based histamine H3 receptor antagonists with anticonvulsant activity in different seizure models in male adult rats
by: Sadek B, et al.
Published: (2016-11-01)

Effects of loratadine, a histamine H1 receptor antagonist, on the skeletal system of young male rats
by: Folwarczna J, et al.
Published: (2019-09-01)

The Histamine H1 Receptor Participates in the Increased Dorsal Telencephalic Neurogenesis in Embryos from Diabetic Rats
by: Karina H. Solís, et al.
Published: (2017-12-01)

Histamine H3 receptor density is negatively correlated with neural activity related to working memory in humans
by: Takehito Ito, et al.
Published: (2018-06-01)

Histamine in regulation of bone remodeling processes
by: Marek Wiercigroch, et al.
Published: (2013-08-01)

Histamine H4 receptor regulates IL-6 and INF-γ secretion in native monocytes from healthy subjects and patients with allergic rhinitis
by: Hua Peng, et al.
Published: (2019-09-01)

QSAR and Molecular Docking Studies on Non-Imidazole-Based Histamine H3 Receptor Antagonists
by: Maryam Hamzeh-Mivehroud, et al.
Published: (2020-06-01)

Use of histamine H2 receptor antagonists and outcomes in patients with heart failure: a nationwide population-based cohort study
by: Adelborg K, et al.
Published: (2018-05-01)

Metabolic benefits of novel histamine H3 receptor ligands in the model of excessive eating: The importance of intrinsic activity and pharmacokinetic properties
by: Kamil Mika, et al.
Published: (2021-10-01)

Pathophysiological Roles of Histamine Receptors in Cancer Progression: Implications and Perspectives as Potential Molecular Targets
by: Phuong Linh Nguyen, et al.
Published: (2021-08-01)

Identification of histaminic (H1-type) receptors in small intestine of broilers by application of histamine and some of its agonists and antagonists
by: Mujezinović Indira, et al.
Published: (2010-01-01)

Histamine can be Formed and Degraded in the Human and Mouse Heart
by: Joachim Neumann, et al.
Published: (2021-05-01)

Pathophysiological Role of Histamine H4 Receptor in Cancer: Therapeutic Implications
by: Melisa B. Nicoud, et al.
Published: (2019-06-01)

Research Advances and Prospects on Mechanism of Sinomenin on Histamine Release and the Binding to Histamine Receptors
by: Yu-Shi Zhang, et al.
Published: (2018-12-01)

Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1)
by: Kihwan Lee, et al.
Published: (2021-06-01)

Bioluminescence Resonance Energy Transfer Based G Protein-Activation Assay to Probe Duration of Antagonism at the Histamine H<sub>3</sub> Receptor
by: Tamara A. M. Mocking, et al.
Published: (2019-07-01)

An inverse agonist of the histamine H3 receptor improves wakefulness in narcolepsy: Studies in orexin−/− mice and patients
by: Jian-Sheng Lin, et al.
Published: (2008-04-01)

Lack of Association Between Rs2067474 Polymorphism in the Histamine Receptor H2 Gene and Gastric Cancer In Latvian Population
by: Moisejevs Georgijs, et al.
Published: (2018-12-01)

Analysis of Missense Variants in the Human Histamine Receptor Family Reveals Increased Constitutive Activity of E410<sup>6.30×30</sup>K Variant in the Histamine H<sub>1</sub> Receptor
by: Xiaoyuan Ma, et al.
Published: (2021-04-01)

In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R−/− and H4R+/+ Mice
by: Bastian Schirmer, et al.
Published: (2018-09-01)

Histamine modulates microglia function
by: Ferreira Raquel, et al.
Published: (2012-05-01)

Antagonism of Histamine H3 receptors Alleviates Pentylenetetrazole-Induced Kindling and Associated Memory Deficits by Mitigating Oxidative Stress, Central Neurotransmitters, and c-Fos Protein Expression in Rats
by: Alaa Alachkar, et al.
Published: (2020-03-01)

Plasticity of the histamine H3 receptors after acute vestibular lesion in the adult cat.
by: Brahim eTighilet, et al.
Published: (2014-01-01)

Specific Engineered G Protein Coupling to Histamine Receptors Revealed from Cellular Assay Experiments and Accelerated Molecular Dynamics Simulations
by: Carina Höring, et al.
Published: (2021-09-01)

Genetic Deficiency of the Histamine H<sub>4</sub>-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice
by: Bastian Schirmer, et al.
Published: (2020-04-01)