Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs

Persistence of Mast Cell-Positive Synovitis in Early Rheumatoid Arthritis Following Treatment With Conventional Synthetic Disease Modifying Anti-Rheumatic Drugs

Mast cells (MCs) are immune cells infiltrating the synovial membrane and implicated in the pathogenesis of Rheumatoid Arthritis (RA). Their infiltration in the synovia of early RA patients has been shown to be associated with systemic inflammation, disease activity and autoantibody positivity. Here,...

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Bibliographic Details
Main Authors: Felice Rivellese, Francesca W. Rossi, Giovanni Giorli, Filomena Napolitano, Amato de Paulis, Costantino Pitzalis
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-07-01
Series:Frontiers in Pharmacology
Subjects:
mast cells
synovitis
synovial membrane
rheumatoid arthritis
inflammation
treatment response
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.01051/full

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