Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats

Dynamic Effects of Early Adolescent Stress on Depressive-Like Behaviors and Expression of Cytokines and JMJD3 in the Prefrontal Cortex and Hippocampus of Rats

Aims: Expression of inflammatory cytokines in the brain has been reported to be involved in the pathogenesis of and susceptibility to depression. Jumonji domain-containing 3 (Jmjd3), which is a histone H3 lysine 27 (H3K27) demethylase and can regulate microglial activation, has been regarded as a cr...

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Bibliographic Details
Main Authors: Rui Wang, Wei Wang, Jingjing Xu, Dexiang Liu, Hong Jiang, Fang Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Psychiatry
Subjects:
Jumonji domain-containing 3
depression
early-life stress
H3K27me3
cytokine
adolescent
Online Access:https://www.frontiersin.org/article/10.3389/fpsyt.2018.00471/full

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