White blood cell counts and neutrophil to lymphocyte ratio in the diagnosis of testicular cancer: a simple secondary serum tumor marker

• Main Authors: Ozgur Haki Yuksel, Ayhan Verit, Aytac Sahin, Ahmet Urkmez, Fatih Uruc
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Urologia 2016-02-01
• Series: International Brazilian Journal of Urology
• Subjects: NLR protein; mouse [Supplementary Concept]; Testicular Neoplasms; Biomarkers, Tumor
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1677-55382016000100053&lng=en&tlng=en

ABSTRACT Purpose The aim of the study was to investigate white blood cell counts and neutrophil to lymphocyte ratio (NLR) as markers of systemic inflammation in the diagnosis of localized testicular cancer as a malignancy with initially low volume. Materials and Methods Thirty-six patients with localized testicular cancer with a mean age of 34.22±14.89 years and 36 healthy controls with a mean age of 26.67±2.89 years were enrolled in the study. White blood cell counts and NLR were calculated from complete blood cell counts. Results White blood cell counts and NLR were statistically significantly higher in patients with testicular cancer compared with the control group (p<0.0001 for all). Conclusions Both white blood cell counts and NLR can be used as a simple test in the diagnosis of testicular cancer besides the well-known accurate serum tumor markers as AFP (alpha fetoprotein), hCG (human chorionic gonadotropin) and LDH (lactate dehydrogenase).