Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration

Biscarbamate Cross-Linked Low-Molecular-Weight Polyethylenimine for Delivering Anti-chordin siRNA into Human Mesenchymal Stem Cells for Improving Bone Regeneration

Small-interfering RNA (siRNA) provides a rapid solution for drug design and provides new methods to develop customizable medicines. Polyethyleneimine 25 kDa (PEI25kDa) is an effective transfection agent used in siRNA delivery. However, the lack of degradable linkage causes undesirable toxicity, hind...

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Bibliographic Details
Main Authors: Chuandong Wang, Weien Yuan, Fei Xiao, Yaokai Gan, Xiaotian Zhao, Zhanjing Zhai, Xiaoying Zhao, Chen Zhao, Penglei Cui, Tuo Jin, Xiaodong Chen, Xiaoling Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-08-01
Series:Frontiers in Pharmacology
Subjects:
low-molecular-weight polyethylenimine
Chordin
human bone mesenchymal stem cells
bone morphogenetic protein-2
osteogenesis
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2017.00572/full

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http://journal.frontiersin.org/article/10.3389/fphar.2017.00572/full

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