Association between GSTP1 Ile105Val polymorphism and urinary system cancer risk: evidence from 51 studies

• Main Authors: Zhang Y, Yuan Y, Chen Y, Wang Z, Li F, Zhao Q
• Format: Article
• Language: English
• Published: Dove Medical Press 2016-06-01
• Series: OncoTargets and Therapy
• Subjects: GSTP1; polymorphism; urinary system cancer; susceptibility; meta-analysis
• Online Access: https://www.dovepress.com/association-between-gstp1-ile105val-polymorphism-and-urinary-system-ca-peer-reviewed-article-OTT

Yixiang Zhang,1 Yeqing Yuan,1 Yufang Chen,2 Zhao Wang,3 Fangfang Li,3 Qingsong Zhao4 1Department of Urology, The Second Affiliated Hospital of Jinan University, Shenzhen People’s Hospital, Shenzhen, Guangdong, 2Department of Pharmacology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, 3Department of Medical Oncology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 4Department of Urology, The First People’s Hospital of Jining, Jining, Shandong, People’s Republic of China Abstract: The GSTP1 gene plays an important role in detoxification of carcinogens. GSTP1 gene polymorphisms may alter the susceptibility of urinary system cancer. Numerous studies have been performed to investigate the association between GSTP1 Ile105Val (rs1695 A>G) polymorphism and urinary system cancer risk. Nevertheless, the results remain controversial and only prostate cancer and bladder cancer are covered. We identified eligible studies from PubMed, Elsevier, and three equivalent Chinese databases including the Chinese National Knowledge Infrastructure, Wanfang, and Weipu. Pooled odds ratios and 95% confidence intervals were used to assess the strength of the association between GSTP1 Ile105Val polymorphism and urinary system cancer risk. In total, 11,762 cases and 15,150 controls from 51 studies were included in the final meta-analysis. The pooled results from all included studies showed a statistically significant association between GSTP1 Ile105Val polymorphism and urinary system cancer. In the subgroup analyses, the GSTP1 Ile105Val polymorphism was found to be significantly associated with prostate cancer risk and also a risk factor for urinary system cancer among Asians. In conclusion, our meta-analysis indicated that GSTP1 Ile105Val polymorphism was associated with urinary system cancer susceptibility, which needs to be validated by more rigorous data from further large-scale population studies with different ethnicities. Keywords: GSTP1, polymorphism, urinary system cancer, susceptibility, meta-analysis