Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice
Anatomical lesions of the preoptic area (POA) can cause sleep loss while electrical, chemical, or thermal stimulation of POA can induce sleep. To better understand the exact neural function of the POA, this study shows that galanin and GABA+ inhibitory neurons in the ventrolateral POA that project t...
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| Format: | Article |
| Language: | English |
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Nature Publishing Group
2018-10-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-06590-7 |
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doaj-e84b4da88d7f473b8b512f6a39eff1b92021-05-11T10:21:45ZengNature Publishing GroupNature Communications2041-17232018-10-019111410.1038/s41467-018-06590-7Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in miceDaniel Kroeger0Gianna Absi1Celia Gagliardi2Sathyajit S. Bandaru3Joseph C. Madara4Loris L. Ferrari5Elda Arrigoni6Heike Münzberg7Thomas E. Scammell8Clifford B. Saper9Ramalingam Vetrivelan10Department of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolNeurobiology of Nutrition and Metabolism, Pennington Biomedical Research Center, Louisiana State University SystemDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolDepartment of Neurology, Program in Neuroscience and Division of Sleep Medicine, Beth Israel Deaconess Medical Center and Harvard Medical SchoolAnatomical lesions of the preoptic area (POA) can cause sleep loss while electrical, chemical, or thermal stimulation of POA can induce sleep. To better understand the exact neural function of the POA, this study shows that galanin and GABA+ inhibitory neurons in the ventrolateral POA that project to the wake-promoting tuberomammillary nucleus promote sleep in a stimulation frequency dependent manner.https://doi.org/10.1038/s41467-018-06590-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Daniel Kroeger Gianna Absi Celia Gagliardi Sathyajit S. Bandaru Joseph C. Madara Loris L. Ferrari Elda Arrigoni Heike Münzberg Thomas E. Scammell Clifford B. Saper Ramalingam Vetrivelan |
| spellingShingle |
Daniel Kroeger Gianna Absi Celia Gagliardi Sathyajit S. Bandaru Joseph C. Madara Loris L. Ferrari Elda Arrigoni Heike Münzberg Thomas E. Scammell Clifford B. Saper Ramalingam Vetrivelan Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice Nature Communications |
| author_facet |
Daniel Kroeger Gianna Absi Celia Gagliardi Sathyajit S. Bandaru Joseph C. Madara Loris L. Ferrari Elda Arrigoni Heike Münzberg Thomas E. Scammell Clifford B. Saper Ramalingam Vetrivelan |
| author_sort |
Daniel Kroeger |
| title |
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice |
| title_short |
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice |
| title_full |
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice |
| title_fullStr |
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice |
| title_full_unstemmed |
Galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice |
| title_sort |
galanin neurons in the ventrolateral preoptic area promote sleep and heat loss in mice |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-10-01 |
| description |
Anatomical lesions of the preoptic area (POA) can cause sleep loss while electrical, chemical, or thermal stimulation of POA can induce sleep. To better understand the exact neural function of the POA, this study shows that galanin and GABA+ inhibitory neurons in the ventrolateral POA that project to the wake-promoting tuberomammillary nucleus promote sleep in a stimulation frequency dependent manner. |
| url |
https://doi.org/10.1038/s41467-018-06590-7 |
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