Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response

Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response

Gene regulatory networks controlling stress response in mycobacterial species have been linked to persistence switches that enable bacterial dormancy within a host. However, the mechanistic basis of switching and stress sensing is not fully understood.

Bibliographic Details
Main Authors: Satyajit D. Rao, Pratik Datta, Maria Laura Gennaro, Oleg A. Igoshin
Format: Article
Language:English
Published: American Society for Microbiology 2021-02-01
Series:mSystems
Online Access:https://journals.asm.org/doi/10.1128/mSystems.00979-20
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spelling doaj-e83c4c1c519741afadfbad51385aedfc2021-09-21T20:43:58ZengAmerican Society for MicrobiologymSystems2379-50772021-02-016110.1128/mSystems.00979-20Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained ResponseSatyajit D. Rao0https://orcid.org/0000-0003-3300-6380Pratik Datta1Maria Laura Gennaro2https://orcid.org/0000-0003-4801-3567Oleg A. Igoshin3https://orcid.org/0000-0002-1449-4772Department of Bioengineering and Center for Theoretical Biological Physics, Rice University, Houston, Texas, USAPublic Health Research Institute, New Jersey Medical School, Newark, New Jersey, USAPublic Health Research Institute, New Jersey Medical School, Newark, New Jersey, USADepartment of Bioengineering and Center for Theoretical Biological Physics, Rice University, Houston, Texas, USA Gene regulatory networks controlling stress response in mycobacterial species have been linked to persistence switches that enable bacterial dormancy within a host. However, the mechanistic basis of switching and stress sensing is not fully understood.https://journals.asm.org/doi/10.1128/mSystems.00979-20
collection DOAJ
language English
format Article
sources DOAJ
author Satyajit D. Rao
Pratik Datta
Maria Laura Gennaro
Oleg A. Igoshin
spellingShingle Satyajit D. Rao
Pratik Datta
Maria Laura Gennaro
Oleg A. Igoshin
Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response
mSystems
author_facet Satyajit D. Rao
Pratik Datta
Maria Laura Gennaro
Oleg A. Igoshin
author_sort Satyajit D. Rao
title Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response
title_short Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response
title_full Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response
title_fullStr Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response
title_full_unstemmed Chaperone-Mediated Stress Sensing in Mycobacterium tuberculosis Enables Fast Activation and Sustained Response
title_sort chaperone-mediated stress sensing in mycobacterium tuberculosis enables fast activation and sustained response
publisher American Society for Microbiology
series mSystems
issn 2379-5077
publishDate 2021-02-01
description Gene regulatory networks controlling stress response in mycobacterial species have been linked to persistence switches that enable bacterial dormancy within a host. However, the mechanistic basis of switching and stress sensing is not fully understood.
url https://journals.asm.org/doi/10.1128/mSystems.00979-20
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AT pratikdatta chaperonemediatedstresssensinginmycobacteriumtuberculosisenablesfastactivationandsustainedresponse
AT marialauragennaro chaperonemediatedstresssensinginmycobacteriumtuberculosisenablesfastactivationandsustainedresponse
AT olegaigoshin chaperonemediatedstresssensinginmycobacteriumtuberculosisenablesfastactivationandsustainedresponse
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