Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Murine host response to Neisseria gonorrhoeae upper genital tract infection reveals a common transcriptional signature, plus distinct inflammatory responses that vary between reproductive cycle phases

Abstract Background The emergence of fully antimicrobial resistant Neisseria gonorrhoeae has led global public health agencies to identify a critical need for next generation anti-gonococcal pharmaceuticals. The development and success of these compounds will rely upon valid pre-clinical models of g...

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Bibliographic Details
Main Authors: Ian P. Francis, Epshita A. Islam, Adam C. Gower, Yazdani B. Shaik-Dasthagirisaheb, Scott D. Gray-Owen, Lee M. Wetzler
Format: Article
Language:English
Published: BMC 2018-08-01
Series:BMC Genomics
Subjects:
Neisseria gonorrhoeae
Gonorrhea
Disease modeling
Murine reproductive cycle
Host immune response
Transcriptome
Online Access:http://link.springer.com/article/10.1186/s12864-018-5000-7

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