Comparison of clot lysis activity and biochemical properties of originator tenecteplase (Metalyse®) with those of an alleged biosimilar

Comparison of clot lysis activity and biochemical properties of originator tenecteplase (Metalyse®) with those of an alleged biosimilar

The bioengineered tissue plasminogen activator tenecteplase is an important treatment modality of acute myocardial infarction recommended by international guidelines. Following introduction of originator tenecteplase (brand names Metalyse® and TNKase®), a ‘biosimilar’ tenecteplase became available f...

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Bibliographic Details
Main Authors: Werner eKliche, Ingo eKrech, Martin C Michel, Nishant V Sangole, Sadhana eSathaye
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-02-01
Series:Frontiers in Pharmacology
Subjects:
Glycosylation
impurity
tenecteplase
biosimilar
clot lysis
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2014.00007/full

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