Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex

Mechanisms of p53 Functional De-Regulation: Role of the IκB-α/p53 Complex

TP53 is one of the most frequently-mutated and deleted tumor suppressors in cancer, with a dramatic correlation with dismal prognoses. In addition to genetic inactivation, the p53 protein can be functionally inactivated in cancer, through post-transductional modifications, changes in cellular compar...

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Bibliographic Details
Main Authors: Giovanna Carrà, Sabrina Crivellaro, Riccardo Taulli, Angelo Guerrasio, Giuseppe Saglio, Alessandro Morotti
Format: Article
Language:English
Published: MDPI AG 2016-11-01
Series:International Journal of Molecular Sciences
Subjects:
p53
IκB-α
tumor suppressors
functional inactivation
Online Access:http://www.mdpi.com/1422-0067/17/12/1997

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