Glycosylation on envelope glycoprotein of duck Tembusu virus affects virus replication in vitro and contributes to the neurovirulence and pathogenicity in vivo

Glycosylation on envelope glycoprotein of duck Tembusu virus affects virus replication in vitro and contributes to the neurovirulence and pathogenicity in vivo

Duck Tembusu virus (DTMUV), an emergent flavivirus, causes domestic waterfowls to suffer from severe egg-drop syndrome and fatal encephalitis, greatly threatens duck production globally. Like other mosquito-borne flaviviruses, the envelope (E) protein of all DTMUV strains was N-glycosylated at the a...

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Bibliographic Details
Main Authors: Dejian Liu, Xuyao Xiao, Peng Zhou, Huijun Zheng, Yaqian Li, Hui Jin, Anan Jongkaewwattana, Rui Luo
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:Virulence
Subjects:
duck tembusu virus
envelope protein
glycosylation
replication
pathogenicity
Online Access:http://dx.doi.org/10.1080/21505594.2021.1974329

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