The Ca2+-activated K+ current of human sperm is mediated by Slo3

The Ca2+-activated K+ current of human sperm is mediated by Slo3

Sperm are equipped with a unique set of ion channels that orchestrate fertilization. In mouse sperm, the principal K+ current (IKSper) is carried by the Slo3 channel, which sets the membrane potential (Vm) in a strongly pHi-dependent manner. Here, we show that IKSper in human sperm is activated weak...

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Bibliographic Details
Main Authors: Christoph Brenker, Yu Zhou, Astrid Müller, Fabio Andres Echeverry, Christian Trötschel, Ansgar Poetsch, Xiao-Ming Xia, Wolfgang Bönigk, Christopher J Lingle, U Benjamin Kaupp, Timo Strünker
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-03-01
Series:eLife
Subjects:
human sperm
ion channel
Slo3
Ca2+-activated K+ channel
patch-clamp recording
Online Access:https://elifesciences.org/articles/01438

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