Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells

Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells

Anaplastic thyroid cancer (ATC) is highly aggressive and tends to develop drug resistance to standard chemotherapies. To overcome the drug resistance of ATC, we synthesized dopamine-melanin nanoparticles (MNPs) loaded with doxorubicin (Dox) molecules. The Dox-loaded MNPs (Dox-MNPs) developed exhibit...

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Main Authors: Kun Wang, Shouju Wang, Kun Chen, Yijing Zhao, Xingqun Ma, Lin Wang
Format: Article
Language:English
Published: Hindawi Limited 2018-01-01
Series:Journal of Nanomaterials
Online Access:http://dx.doi.org/10.1155/2018/2603712
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spelling doaj-e82926064e524c918d846bd64ef2dced2020-11-24T21:15:19ZengHindawi LimitedJournal of Nanomaterials1687-41101687-41292018-01-01201810.1155/2018/26037122603712Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer CellsKun Wang0Shouju Wang1Kun Chen2Yijing Zhao3Xingqun Ma4Lin Wang5Department of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaDepartment of Medical Imaging, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210000, ChinaDepartment of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaDepartment of Endocrinology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, ChinaDepartment of Oncology, The Affiliated Bayi Hospital of Nanjing University of Chinese Medicine, Nanjing 210002, ChinaDepartment of Oncology, The Affiliated Bayi Hospital of Nanjing University of Chinese Medicine, Nanjing 210002, ChinaAnaplastic thyroid cancer (ATC) is highly aggressive and tends to develop drug resistance to standard chemotherapies. To overcome the drug resistance of ATC, we synthesized dopamine-melanin nanoparticles (MNPs) loaded with doxorubicin (Dox) molecules. The Dox-loaded MNPs (Dox-MNPs) developed exhibited increased cellular uptake and enhanced therapeutic efficacy in drug-resistant ATC cell line HTh74R, compared with free Dox. The native MNPs were found to have excellent biocompatibility, which suggests that Dox-MNPs may have potential in the treatment of ATC.http://dx.doi.org/10.1155/2018/2603712
collection DOAJ
language English
format Article
sources DOAJ
author Kun Wang
Shouju Wang
Kun Chen
Yijing Zhao
Xingqun Ma
Lin Wang
spellingShingle Kun Wang
Shouju Wang
Kun Chen
Yijing Zhao
Xingqun Ma
Lin Wang
Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
Journal of Nanomaterials
author_facet Kun Wang
Shouju Wang
Kun Chen
Yijing Zhao
Xingqun Ma
Lin Wang
author_sort Kun Wang
title Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
title_short Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
title_full Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
title_fullStr Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
title_full_unstemmed Doxorubicin-Loaded Melanin Particles for Enhanced Chemotherapy in Drug-Resistant Anaplastic Thyroid Cancer Cells
title_sort doxorubicin-loaded melanin particles for enhanced chemotherapy in drug-resistant anaplastic thyroid cancer cells
publisher Hindawi Limited
series Journal of Nanomaterials
issn 1687-4110
1687-4129
publishDate 2018-01-01
description Anaplastic thyroid cancer (ATC) is highly aggressive and tends to develop drug resistance to standard chemotherapies. To overcome the drug resistance of ATC, we synthesized dopamine-melanin nanoparticles (MNPs) loaded with doxorubicin (Dox) molecules. The Dox-loaded MNPs (Dox-MNPs) developed exhibited increased cellular uptake and enhanced therapeutic efficacy in drug-resistant ATC cell line HTh74R, compared with free Dox. The native MNPs were found to have excellent biocompatibility, which suggests that Dox-MNPs may have potential in the treatment of ATC.
url http://dx.doi.org/10.1155/2018/2603712
work_keys_str_mv AT kunwang doxorubicinloadedmelaninparticlesforenhancedchemotherapyindrugresistantanaplasticthyroidcancercells
AT shoujuwang doxorubicinloadedmelaninparticlesforenhancedchemotherapyindrugresistantanaplasticthyroidcancercells
AT kunchen doxorubicinloadedmelaninparticlesforenhancedchemotherapyindrugresistantanaplasticthyroidcancercells
AT yijingzhao doxorubicinloadedmelaninparticlesforenhancedchemotherapyindrugresistantanaplasticthyroidcancercells
AT xingqunma doxorubicinloadedmelaninparticlesforenhancedchemotherapyindrugresistantanaplasticthyroidcancercells
AT linwang doxorubicinloadedmelaninparticlesforenhancedchemotherapyindrugresistantanaplasticthyroidcancercells
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