A Ciliary Protein EVC2/LIMBIN Plays a Critical Role in the Skull Base for Mid-Facial Development

A Ciliary Protein EVC2/LIMBIN Plays a Critical Role in the Skull Base for Mid-Facial Development

Ellis-van Creveld (EvC) syndrome is an autosomal recessive chondrodysplastic disorder. Affected patients present a wide spectrum of symptoms including short stature, postaxial polydactyly, and dental abnormalities. We previously disrupted Evc2, one of the causative genes for EvC syndrome, in mice us...

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Bibliographic Details
Main Authors: Anshul K. Kulkarni, Ke’ale W. Louie, Marilia Yatabe, Antonio Carlos de Oliveira Ruellas, Yoshiyuki Mochida, Lucia H. S. Cevidanes, Yuji Mishina, Honghao Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-10-01
Series:Frontiers in Physiology
Subjects:
EvC syndrome
Evc2
Limbin
ciliopathy
mid-facial defects
skull base
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2018.01484/full

Internet

https://www.frontiersin.org/article/10.3389/fphys.2018.01484/full

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