Abnormal expression of TFIIIB subunits and RNA Pol III genes is associated with hepatocellular carcinoma

The levels of the products of RNA polymerase III-dependent genes (Pol III genes), including tRNAs and 5S rRNA, are elevated in transformed and tumor cells, which potentiate tumorigenesis. TFIIB-related factor 1 (Brf1) is a key transcription factor and specifically regulates the transcription of Pol...

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Bibliographic Details
Main Authors: Junxia Lei, Songlin Chen, Shuping Zhong
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2017-09-01
Series:Liver Research
Online Access:http://www.sciencedirect.com/science/article/pii/S2542568417000320