Tumor Secretome to Adoptive Cellular Immunotherapy: Reduce Me Before I Make You My Partner

Tumor Secretome to Adoptive Cellular Immunotherapy: Reduce Me Before I Make You My Partner

Adoptive cellular immunotherapy using chimeric antigen receptor (CAR)-modified T cells and Natural Killer (NK) cells are common immune cell sources administered to treat cancer patients. In detail, whereas CAR-T cells induce outstanding responses in a subset of hematological malignancies, responses...

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Bibliographic Details
Main Authors: Mikel Etxebeste-Mitxeltorena, Inés del Rincón-Loza, Beatriz Martín-Antonio
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Immunology
Subjects:
tumor secretome
SASP
senescence
immunotherapy
macrophages
CAR-T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.717850/full

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