Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.

Analysis of the Putative Role of CR1 in Alzheimer's Disease: Genetic Association, Expression and Function.

Chronic activation of the complement system and induced inflammation are associated with neuropathology in Alzheimer's disease (AD). Recent large genome wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) in the C3b/C4b receptor (CR1 or CD35) that are associat...

Full description

Bibliographic Details
Main Authors: Maria I Fonseca, Shuhui Chu, Aimee L Pierce, William D Brubaker, Richard E Hauhart, Diego Mastroeni, Elizabeth V Clarke, Joseph Rogers, John P Atkinson, Andrea J Tenner
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4767815?pdf=render

Similar Items

Similar Items