Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid

Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid

New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2)....

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Bibliographic Details
Main Authors: M. Aouad, N. Rezki, R. Al-Bayati, A. Sharba
Format: Article
Language:English
Published: MDPI AG 2005-09-01
Series:Molecules
Subjects:
Bis-thiadiazolylcyclopropane
bis–triazolylcyclopropane
azomethines
Mannich bases.
Online Access:http://www.mdpi.com/1420-3049/10/9/1153/
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spelling doaj-e8095fbadb8e4f3aa19e2785cdcefb7c2020-11-24T23:37:19ZengMDPI AGMolecules1420-30492005-09-011091153116010.3390/10091153Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic AcidM. AouadN. RezkiR. Al-BayatiA. SharbaNew heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.http://www.mdpi.com/1420-3049/10/9/1153/Bis-thiadiazolylcyclopropanebis–triazolylcyclopropaneazomethinesMannich bases.
collection DOAJ
language English
format Article
sources DOAJ
author M. Aouad
N. Rezki
R. Al-Bayati
A. Sharba
spellingShingle M. Aouad
N. Rezki
R. Al-Bayati
A. Sharba
Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid
Molecules
Bis-thiadiazolylcyclopropane
bis–triazolylcyclopropane
azomethines
Mannich bases.
author_facet M. Aouad
N. Rezki
R. Al-Bayati
A. Sharba
author_sort M. Aouad
title Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid
title_short Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid
title_full Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid
title_fullStr Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid
title_full_unstemmed Synthesis of Thiadiazoles and 1,2,4-Triazoles Derived from Cyclopropane Dicarboxylic Acid
title_sort synthesis of thiadiazoles and 1,2,4-triazoles derived from cyclopropane dicarboxylic acid
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2005-09-01
description New heterocyclic derivatives of cyclopropane dicarboxylic acid comprising thiadiazole and 1,2,4-triazole moieties are reported. Reaction of 1,1-cyclopropane dicarboxylic acid (1) with thiosemicarbazide and phosphorous oxychloride resulted in 1,1-bis (2-amino-1,3,4-thiadiazol-5- yl)cyclopropane (2). Cyclopropane dicarboxylic acid thiosemicarbazide (6) was converted into 1,1-bis(3-thio-4H-1,2,4-triazol-5-yl) cyclo- propane (7) by ring closure in an alkaline medium. The thiadiazole 2 and the triazole 7 were converted into a variety of derivatives.
topic Bis-thiadiazolylcyclopropane
bis–triazolylcyclopropane
azomethines
Mannich bases.
url http://www.mdpi.com/1420-3049/10/9/1153/
work_keys_str_mv AT maouad synthesisofthiadiazolesand124triazolesderivedfromcyclopropanedicarboxylicacid
AT nrezki synthesisofthiadiazolesand124triazolesderivedfromcyclopropanedicarboxylicacid
AT ralbayati synthesisofthiadiazolesand124triazolesderivedfromcyclopropanedicarboxylicacid
AT asharba synthesisofthiadiazolesand124triazolesderivedfromcyclopropanedicarboxylicacid
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