Surface-Modification of Carbonate Apatite Nanoparticles Enhances Delivery and Cytotoxicity of Gemcitabine and Anastrozole in Breast Cancer Cells

Surface-Modification of Carbonate Apatite Nanoparticles Enhances Delivery and Cytotoxicity of Gemcitabine and Anastrozole in Breast Cancer Cells

pH sensitive nanoparticles of carbonate apatite (CA) have been proven to be effective delivery vehicles for DNA, siRNAs and proteins. More recently, conventional anti-cancer drugs, such as doxorubicin, methotrexate and cyclophosphamide have been successfully incorporated into CA for intracellular de...

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Bibliographic Details
Main Authors:	Fitya Syarifa Mozar, Ezharul Hoque Chowdhury
Format:	Article
Language:	English
Published:	MDPI AG 2017-06-01
Series:	Pharmaceutics
Subjects:	carbonate apatite (CA) nanoparticles (NPs) intracellular delivery breast cancer cells hydrophobicity hydrophilicity cellular uptake cytotoxicity anastrozole gemcitabine
Online Access:	http://www.mdpi.com/1999-4923/9/2/21

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