Heparanase Expression in Circulating Lymphocytes of Breast Cancer Patients Depends on the Presence of the Primary Tumor and/or Systemic Metastasis

Heparanase Expression in Circulating Lymphocytes of Breast Cancer Patients Depends on the Presence of the Primary Tumor and/or Systemic Metastasis

Heparanase is an endo-β-glucuronidase that is capable of degrading heparan sulfate chains of proteoglycans, generating a variety of bioactive molecules such as growth factors and chemotactic and angiogenic agents. The expression of heparanase was investigated in the peripheral blood mononuclear cel...

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Bibliographic Details
Main Authors: Thérése Rachell Theodoro, Leandro Luongo de Matos, Aleksandra Vanessa Lambiasi Sant Anna, Fernando Luiz Affonso Fonseca, Patrícia Semedo, Lourdes Conceição Martins, Helena Bonciani Nader, Auro Del Giglio, Maria Aparecida da Silva Pinhal
Format: Article
Language:English
Published: Elsevier 2007-06-01
Series:Neoplasia: An International Journal for Oncology Research
Subjects:
Heparanase
breast cancer
lymphocytes
tumor markers
metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558607800078

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