Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat Heart From Type-1 Diabetes

Addition of the Aldose Reductase Inhibitor Benzofuroxane Derivative BF-5m to Prolonged and Moderate Exercise Training Enhanced Protection of the Rat Heart From Type-1 Diabetes

Moderate exercise training may not be sufficient to exert beneficial effects on the cardiovascular system because of the long-term multifactorial etiology of diabetic complications. The addition of a proper pharmacological tool to the physical exercise should improve the outcomes of the diabetic dam...

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Bibliographic Details
Main Authors: Bartolo Ferraro, Maria Donniacuo, Loredana Sodano, Franca Ferraraccio, Rosa Maisto, Eliana Gulotta, Gorizio Pieretti, Michele D’Amico, Maria Consiglia Trotta, Barbara Rinaldi
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Pharmacology
Subjects:
diabetes
aldose-reductase
benzofuroxane
exercise
QT interval
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.00392/full

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