Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans

Chromoanasynthesis is a recently discovered phenomenon in humans with congenital diseases that is characterized by complex genomic rearrangements (CGRs) resulting from aberrant repair of catastrophic chromosomal damage. How these CGRs are induced is not known. Here, we describe the structure and fun...

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Bibliographic Details
Main Authors: Omar A. Itani, Stephane Flibotte, Kathleen J. Dumas, Donald G. Moerman, Patrick J. Hu
Format: Article
Language:English
Published: Oxford University Press 2016-02-01
Series:G3: Genes, Genomes, Genetics
Subjects:
chromoanasynthesis
chromothripsis
C. elegans
insulin-like growth factor signaling
dauer
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.115.024257

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