Allergic reaction to intravenous atropine in a patient with organophosphate poisoning

• Main Authors: Shiva Samsamshariat, Navid Honarjoo, Farzad Gheshlaghi, Gholamali Dorvashy, Nastaran Eizadi-Mood
• Format: Article
• Language: English
• Published: Wolters Kluwer Medknow Publications 2019-01-01
• Series: Journal of Research in Pharmacy Practice
• Subjects: Allergic reaction; Atropine; organophosphate poisoning; urticaria
• Online Access: http://www.jrpp.net/article.asp?issn=2319-9644;year=2019;volume=8;issue=1;spage=33;epage=34;aulast=Samsamshariat

Atropine is a drug of choice for muscarinic effects in organophosphate (OP) poisoning. Allergic reaction to atropine is rare. Here, we report a case of a 17-year-old male who was admitted with clinical manifestations of acute OP poisoning. After intravenous atropine injection, cutaneous signs of hypersensitivity including erythema and urticarial were observed on his body. Atropine injection was stopped, and antihistamines and hydrocortisone were administered. His condition was improved, and he discharged with a good condition after 2 days hospitalization. Adverse allergic reaction to atropine should be in mind when managing OP poisoning cases.