Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors

Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors

Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influe...

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Bibliographic Details
Main Authors: Kalina Duszka, Walter Wahli
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:International Journal of Molecular Sciences
Subjects:
nuclear receptors
microbiota
metabolism
xenobiotics
Online Access:http://www.mdpi.com/1422-0067/19/8/2210
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spelling doaj-e7eca2416164478986388d66729594412020-11-24T22:15:52ZengMDPI AGInternational Journal of Molecular Sciences1422-00672018-07-01198221010.3390/ijms19082210ijms19082210Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear ReceptorsKalina Duszka0Walter Wahli1Department of Nutritional Sciences, University of Vienna, Althanstrasse 14, 1090 Vienna, AustriaLee Kong Chian School of Medicine, Nanyang Technological University, 11 Mandalay Road, Singapore 308232, SingaporeNuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis.http://www.mdpi.com/1422-0067/19/8/2210nuclear receptorsmicrobiotametabolismxenobiotics
collection DOAJ
language English
format Article
sources DOAJ
author Kalina Duszka
Walter Wahli
spellingShingle Kalina Duszka
Walter Wahli
Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
International Journal of Molecular Sciences
nuclear receptors
microbiota
metabolism
xenobiotics
author_facet Kalina Duszka
Walter Wahli
author_sort Kalina Duszka
title Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_short Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_full Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_fullStr Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_full_unstemmed Enteric Microbiota–Gut–Brain Axis from the Perspective of Nuclear Receptors
title_sort enteric microbiota–gut–brain axis from the perspective of nuclear receptors
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1422-0067
publishDate 2018-07-01
description Nuclear receptors (NRs) play a key role in regulating virtually all body functions, thus maintaining a healthy operating body with all its complex systems. Recently, gut microbiota emerged as major factor contributing to the health of the whole organism. Enteric bacteria have multiple ways to influence their host and several of them involve communication with the brain. Mounting evidence of cooperation between gut flora and NRs is already available. However, the full potential of the microbiota interconnection with NRs remains to be uncovered. Herewith, we present the current state of knowledge on the multifaceted roles of NRs in the enteric microbiota–gut–brain axis.
topic nuclear receptors
microbiota
metabolism
xenobiotics
url http://www.mdpi.com/1422-0067/19/8/2210
work_keys_str_mv AT kalinaduszka entericmicrobiotagutbrainaxisfromtheperspectiveofnuclearreceptors
AT walterwahli entericmicrobiotagutbrainaxisfromtheperspectiveofnuclearreceptors
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