Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis

Epigenetic modifications, such as DNA methylation, play an important role in adult neurogenesis. Here the authors show that Tet2, which converts 5mC to 5hmC, interacts with the transcription factor Foxo3a and regulates critical genes related to the proliferation and differentiation of adult neural s...

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Main Authors:	Xuekun Li, Bing Yao, Li Chen, Yunhee Kang, Yujing Li, Ying Cheng, Liping Li, Li Lin, Zhiqin Wang, Mengli Wang, Feng Pan, Qing Dai, Wei Zhang, Hao Wu, Qiang Shu, Zhaohui Qin, Chuan He, Mingjiang Xu, Peng Jin
Format:	Article
Language:	English
Published:	Nature Publishing Group 2017-06-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms15903

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spelling	doaj-e7eae03bda61408dacebbc67da52c91f2021-05-11T07:54:07ZengNature Publishing GroupNature Communications2041-17232017-06-018111410.1038/ncomms15903Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesisXuekun Li0Bing Yao1Li Chen2Yunhee Kang3Yujing Li4Ying Cheng5Liping Li6Li Lin7Zhiqin Wang8Mengli Wang9Feng Pan10Qing Dai11Wei Zhang12Hao Wu13Qiang Shu14Zhaohui Qin15Chuan He16Mingjiang Xu17Peng Jin18The Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang UniversityDepartment of Human Genetics, Emory University School of MedicineDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory UniversityDepartment of Human Genetics, Emory University School of MedicineDepartment of Human Genetics, Emory University School of MedicineDepartment of Human Genetics, Emory University School of MedicineThe Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang UniversityGuangdong-Hongkong-Macau Institute of CNS Regeneration, Joint International Research Laboratory of CNS Regeneration, Ministry of Education of PRC, Jinan UniversityDepartment of Human Genetics, Emory University School of MedicineDepartment of Human Genetics, Emory University School of MedicineDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of MedicineDepartment of Chemistry, University of ChicagoCollege of Business, Iowa State UniversityDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory UniversityThe Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang UniversityDepartment of Biostatistics and Bioinformatics, Rollins School of Public Health, Emory UniversityDepartment of Chemistry, University of ChicagoDepartment of Biochemistry and Molecular Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of MedicineThe Children’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang UniversityEpigenetic modifications, such as DNA methylation, play an important role in adult neurogenesis. Here the authors show that Tet2, which converts 5mC to 5hmC, interacts with the transcription factor Foxo3a and regulates critical genes related to the proliferation and differentiation of adult neural stem cells.https://doi.org/10.1038/ncomms15903
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Xuekun Li Bing Yao Li Chen Yunhee Kang Yujing Li Ying Cheng Liping Li Li Lin Zhiqin Wang Mengli Wang Feng Pan Qing Dai Wei Zhang Hao Wu Qiang Shu Zhaohui Qin Chuan He Mingjiang Xu Peng Jin
spellingShingle	Xuekun Li Bing Yao Li Chen Yunhee Kang Yujing Li Ying Cheng Liping Li Li Lin Zhiqin Wang Mengli Wang Feng Pan Qing Dai Wei Zhang Hao Wu Qiang Shu Zhaohui Qin Chuan He Mingjiang Xu Peng Jin Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis Nature Communications
author_facet	Xuekun Li Bing Yao Li Chen Yunhee Kang Yujing Li Ying Cheng Liping Li Li Lin Zhiqin Wang Mengli Wang Feng Pan Qing Dai Wei Zhang Hao Wu Qiang Shu Zhaohui Qin Chuan He Mingjiang Xu Peng Jin
author_sort	Xuekun Li
title	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
title_short	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
title_full	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
title_fullStr	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
title_full_unstemmed	Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis
title_sort	ten-eleven translocation 2 interacts with forkhead box o3 and regulates adult neurogenesis
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2017-06-01
description	Epigenetic modifications, such as DNA methylation, play an important role in adult neurogenesis. Here the authors show that Tet2, which converts 5mC to 5hmC, interacts with the transcription factor Foxo3a and regulates critical genes related to the proliferation and differentiation of adult neural stem cells.
url	https://doi.org/10.1038/ncomms15903
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Ten-eleven translocation 2 interacts with forkhead box O3 and regulates adult neurogenesis

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