B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren’s Syndrome

B Cells Are Indispensable for a Novel Mouse Model of Primary Sjögren’s Syndrome

Primary Sjögren’s syndrome (pSS) is characterized by a panel of autoantibodies, while it is not clear whether B cells and autoantibodies play an essential role in pathogenesis of the disease. Here, we report a novel mouse model for pSS which is induced by immunization with the Ro60_316-335 peptide c...

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Bibliographic Details
Main Authors: Junfeng Zheng, Qiaoniang Huang, Renliang Huang, Fengyuan Deng, Xiaoyang Yue, Junping Yin, Wenjie Zhao, Yan Chen, Lifang Wen, Jun Zhou, Renda Huang, Gabriela Riemekasten, Zuguo Liu, Frank Petersen, Xinhua Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-10-01
Series:Frontiers in Immunology
Subjects:
primary Sjögren’s syndrome
mouse model
T cell epitope
SSA
autoantibodies
B cells
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01384/full

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