PlGF and VEGF-A Regulate Growth of High-Risk MYCN-Single Copy Neuroblastoma Xenografts via Different Mechanisms

PlGF and VEGF-A Regulate Growth of High-Risk MYCN-Single Copy Neuroblastoma Xenografts via Different Mechanisms

Neuroblastoma (NB) is the most common extracranial solid tumor of childhood and is a rapidly growing, highly-vascularized cancer. NBs frequently express angiogenic factors and high tumor angiogenesis has been associated with poor outcomes. Placental growth factor (PlGF) is an angiogenic protein belo...

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Bibliographic Details
Main Authors: Karin Zins, Daniel Kovatchki, Trevor Lucas, Dietmar Abraham
Format: Article
Language:English
Published: MDPI AG 2016-09-01
Series:International Journal of Molecular Sciences
Subjects:
placental growth factor
vascular endothelial growth factor A
vascular endothelial growth factor receptor 2
neuroblastoma
xenograft model
Online Access:http://www.mdpi.com/1422-0067/17/10/1613

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