GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging

GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging

Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated...

Full description

Bibliographic Details
Main Authors:	Jin Young Lee, Kyung-Rok Yu, Byung-Chul Lee, Insung Kang, Jae-Jun Kim, Eui-Jung Jung, Hyung-Sik Kim, Yoojin Seo, Soon Won Choi, Kyung-Sun Kang
Format:	Article
Language:	English
Published:	Nature Publishing Group 2018-05-01
Series:	Experimental and Molecular Medicine
Online Access:	https://doi.org/10.1038/s12276-018-0092-3

Similar Items

Therapeutic Features and Updated Clinical Trials of Mesenchymal Stem Cell (MSC)-Derived Exosomes
by: Byung-Chul Lee, et al.
Published: (2021-02-01)

Strategies to Potentiate Paracrine Therapeutic Efficacy of Mesenchymal Stem Cells in Inflammatory Diseases
by: Yoojin Seo, et al.
Published: (2021-03-01)

A p38 MAPK-mediated alteration of COX-2/PGE2 regulates immunomodulatory properties in human mesenchymal stem cell aging.
by: Kyung-Rok Yu, et al.
Published: (2014-01-01)

Donor-dependent variation of human umbilical cord blood mesenchymal stem cells in response to hypoxic preconditioning and amelioration of limb ischemia
by: Insung Kang, et al.
Published: (2018-04-01)

Functional enhancement strategies for immunomodulation of mesenchymal stem cells and their therapeutic application
by: Byung-Chul Lee, et al.
Published: (2020-09-01)

Stem cell-secreted 14,15- epoxyeicosatrienoic acid rescues cholesterol homeostasis and autophagic flux in Niemann–Pick-type C disease
by: Insung Kang, et al.
Published: (2018-11-01)

MIS416 Enhances Therapeutic Functions of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Against Experimental Colitis by Modulating Systemic Immune Milieu
by: Byung-Chul Lee, et al.
Published: (2018-05-01)

Single-Factor SOX2 Mediates Direct Neural Reprogramming of Human Mesenchymal Stem Cells via Transfection of Transcribed mRNA
by: Bo-Eun Kim, et al.
Published: (2018-07-01)

Mesenchymal Stem Cell Therapy for Inflammatory Skin Diseases: Clinical Potential and Mode of Action
by: Tae-Hoon Shin, et al.
Published: (2017-01-01)

Current Advances in Red Blood Cell Generation Using Stem Cells from Diverse Sources
by: Yoojin Seo, et al.
Published: (2019-01-01)

Investigation of optimal lamination condition of CFRTP by compression molding method and a comparison of mechanical properties with CFRTS
by: Dae Won Kim, et al.
Published: (2020-12-01)

Antioxidant Properties of Tonsil-Derived Mesenchymal Stem Cells on Human Vocal Fold Fibroblast Exposed to Oxidative Stress
by: Sung-Chan Shin, et al.
Published: (2020-01-01)

Betulinic Acid Protects DOX-Triggered Cardiomyocyte Hypertrophy Response through the GATA-4/Calcineurin/NFAT Pathway
by: Jung Joo Yoon, et al.
Published: (2021-12-01)

Overexpression of human GATA-1 and GATA-2 interferes with spine formation and produces depressive behavior in rats.
by: Miyeon Choi, et al.
Published: (2014-01-01)

A Novel Secretory Vesicle from Deer Antlerogenic Mesenchymal Stem Cell-Conditioned Media (DaMSC-CM) Promotes Tissue Regeneration
by: Minkoo Seo, et al.
Published: (2018-01-01)

Tensin-3 Regulates Integrin-Mediated Proliferation and Differentiation of Tonsil-Derived Mesenchymal Stem Cells
by: Gi Cheol Park, et al.
Published: (2019-12-01)

TNF-α Priming Elicits Robust Immunomodulatory Potential of Human Tonsil-Derived Mesenchymal Stem Cells to Alleviate Murine Colitis
by: Tae-Hoon Shin, et al.
Published: (2020-12-01)

Epidural Fat-Derived Mesenchymal Stem Cell: First Report of Epidural Fat-Derived Mesenchymal Stem Cell
by: Gun Woo Lee, et al.
Published: (2019-06-01)

Superoxide Dismutase 3-Transduced Mesenchymal Stem Cells Preserve Epithelial Tight Junction Barrier in Murine Colitis and Attenuate Inflammatory Damage in Epithelial Organoids
by: Lee-Jung Tak, et al.
Published: (2021-06-01)

Implication of NOD1 and NOD2 for the differentiation of multipotent mesenchymal stem cells derived from human umbilical cord blood.
by: Hyung-Sik Kim, et al.
Published: (2010-01-01)

<i>Cryptotympana pustulata</i> Extract and Its Main Active Component, Oleic Acid, Inhibit Ovalbumin-Induced Allergic Airway Inflammation through Inhibition of Th2/GATA-3 and Interleukin-17/RORγt Signaling Pathways in Asthmatic Mice
by: Seung-Hyung Kim, et al.
Published: (2021-03-01)

GATA25, a novel regulator, accelerates the flowering time of Arabidopsis thaliana
by: Kang, T.-A, et al.
Published: (2022)

Stem Cell-Derived Extracellular Vesicles as Immunomodulatory Therapeutics
by: Yoojin Seo, et al.
Published: (2019-01-01)

The effect of mesh division of a volume source on calculated radiation flux distribution
by: Kim Kyung-O, et al.
Published: (2015-01-01)

Prediction of Bending Stiffness for Laminated CFRP and Its Application to Manufacturing of Roof Reinforcement
by: Jeong-Min Lee, et al.
Published: (2014-05-01)

Subculture of Germ Cell-Derived Colonies with GATA4-Positive Feeder Cells from Neonatal Pig Testes
by: Kyung Hoon Lee, et al.
Published: (2016-01-01)

Prediction of withdrawal resistance for a screw in hybrid cross-laminated timber
by: Sung-Jun Pang, et al.
Published: (2020-11-01)

A Literature Analysis on Medicinal Use and Research of Cannabis in the Meiji Era of Japan
by: Byung-Soo Ahn, et al.
Published: (2020-09-01)

Current Strategies to Enhance Adipose Stem Cell Function: An Update
by: Yoojin Seo, et al.
Published: (2019-08-01)

Loss of RNA binding protein HuD facilitates the production of the senescence-associated secretory phenotype
by: Cha, S., et al.
Published: (2022)

Extracellular Vesicles from SOD3-Transduced Stem Cells Exhibit Improved Immunomodulatory Abilities in the Murine Dermatitis Model
by: Ji Won Yang, et al.
Published: (2020-11-01)

The effect of three-dimensional cultured adipose tissue-derived mesenchymal stem cell–conditioned medium and the antiaging effect of cosmetic products containing the medium
by: Kyung Hye Kim, et al.
Published: (2019-12-01)

Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Protect against Neuronal Cell Death and Ameliorate Motor Deficits in Niemann Pick Type C1 Mice
by: Yoojin Seo, et al.
Published: (2011-08-01)

Enhanced osteogenic commitment of murine mesenchymal stem cells on graphene oxide substrate
by: Jiyong Kim, et al.
Published: (2018-01-01)

Genetic variations in the transcription factors GATA4 and GATA6 and bleeding complications in patients receiving warfarin therapy
by: Yee J, et al.
Published: (2019-05-01)

DNA methyltransferase controls stem cell aging by regulating BMI1 and EZH2 through microRNAs.
by: Ah-Young So, et al.
Published: (2011-05-01)

Secretory Breast Carcinoma: A Case Report with MRI Findings
by: Sung Hee Shin, et al.
Published: (2019-07-01)

Inverse association between glycated albumin and insulin secretory function may explain higher levels of glycated albumin in subjects with longer duration of diabetes.
by: Yong-ho Lee, et al.
Published: (2014-01-01)

REX-1 expression and p38 MAPK activation status can determine proliferation/differentiation fates in human mesenchymal stem cells.
by: Dilli Ram Bhandari, et al.
Published: (2010-05-01)

The effect of statin on epithelial-mesenchymal transition in peritoneal mesothelial cells.
by: Tae Ik Chang, et al.
Published: (2014-01-01)

Cannot write session to /tmp/vufind_sessions/sess_c0uimbnsdn2s621am004j2vge4