GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging

Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated...

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Main Authors: Jin Young Lee, Kyung-Rok Yu, Byung-Chul Lee, Insung Kang, Jae-Jun Kim, Eui-Jung Jung, Hyung-Sik Kim, Yoojin Seo, Soon Won Choi, Kyung-Sun Kang
Format: Article
Language:English
Published: Nature Publishing Group 2018-05-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-018-0092-3
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spelling doaj-e7de86492fdb47c5ab2f3e2699761f3a2020-12-08T13:51:14ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132018-05-0150511210.1038/s12276-018-0092-3GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell agingJin Young Lee0Kyung-Rok Yu1Byung-Chul Lee2Insung Kang3Jae-Jun Kim4Eui-Jung Jung5Hyung-Sik Kim6Yoojin Seo7Soon Won Choi8Kyung-Sun Kang9Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityPusan National University School of MedicinePusan National University School of MedicineAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated the protein network known as the nuclear lamina. They studied a specific type of human stem cell that gives rise to bone, cartilage, muscle and fat. They found that altering the levels of proteins produced by specific key genes promotes cell aging, and the alterations led to abnormalities in the proteins of the nuclear lamina. The researchers suggest that their work provides new insights into the molecular and cellular causes of premature and normal aging. Understanding the molecular triggers of aging could lead to treatments to delay both its normal and disease-linked forms.https://doi.org/10.1038/s12276-018-0092-3
collection DOAJ
language English
format Article
sources DOAJ
author Jin Young Lee
Kyung-Rok Yu
Byung-Chul Lee
Insung Kang
Jae-Jun Kim
Eui-Jung Jung
Hyung-Sik Kim
Yoojin Seo
Soon Won Choi
Kyung-Sun Kang
spellingShingle Jin Young Lee
Kyung-Rok Yu
Byung-Chul Lee
Insung Kang
Jae-Jun Kim
Eui-Jung Jung
Hyung-Sik Kim
Yoojin Seo
Soon Won Choi
Kyung-Sun Kang
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
Experimental and Molecular Medicine
author_facet Jin Young Lee
Kyung-Rok Yu
Byung-Chul Lee
Insung Kang
Jae-Jun Kim
Eui-Jung Jung
Hyung-Sik Kim
Yoojin Seo
Soon Won Choi
Kyung-Sun Kang
author_sort Jin Young Lee
title GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
title_short GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
title_full GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
title_fullStr GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
title_full_unstemmed GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
title_sort gata4-dependent regulation of the secretory phenotype via mcp-1 underlies lamin a-mediated human mesenchymal stem cell aging
publisher Nature Publishing Group
series Experimental and Molecular Medicine
issn 1226-3613
2092-6413
publishDate 2018-05-01
description Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated the protein network known as the nuclear lamina. They studied a specific type of human stem cell that gives rise to bone, cartilage, muscle and fat. They found that altering the levels of proteins produced by specific key genes promotes cell aging, and the alterations led to abnormalities in the proteins of the nuclear lamina. The researchers suggest that their work provides new insights into the molecular and cellular causes of premature and normal aging. Understanding the molecular triggers of aging could lead to treatments to delay both its normal and disease-linked forms.
url https://doi.org/10.1038/s12276-018-0092-3
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