GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging
Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated...
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2018-05-01
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doaj-e7de86492fdb47c5ab2f3e2699761f3a2020-12-08T13:51:14ZengNature Publishing GroupExperimental and Molecular Medicine1226-36132092-64132018-05-0150511210.1038/s12276-018-0092-3GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell agingJin Young Lee0Kyung-Rok Yu1Byung-Chul Lee2Insung Kang3Jae-Jun Kim4Eui-Jung Jung5Hyung-Sik Kim6Yoojin Seo7Soon Won Choi8Kyung-Sun Kang9Adult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityPusan National University School of MedicinePusan National University School of MedicineAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAdult Stem Cell Research Center, College of Veterinary Medicine, Seoul National UniversityAging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated the protein network known as the nuclear lamina. They studied a specific type of human stem cell that gives rise to bone, cartilage, muscle and fat. They found that altering the levels of proteins produced by specific key genes promotes cell aging, and the alterations led to abnormalities in the proteins of the nuclear lamina. The researchers suggest that their work provides new insights into the molecular and cellular causes of premature and normal aging. Understanding the molecular triggers of aging could lead to treatments to delay both its normal and disease-linked forms.https://doi.org/10.1038/s12276-018-0092-3 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jin Young Lee Kyung-Rok Yu Byung-Chul Lee Insung Kang Jae-Jun Kim Eui-Jung Jung Hyung-Sik Kim Yoojin Seo Soon Won Choi Kyung-Sun Kang |
spellingShingle |
Jin Young Lee Kyung-Rok Yu Byung-Chul Lee Insung Kang Jae-Jun Kim Eui-Jung Jung Hyung-Sik Kim Yoojin Seo Soon Won Choi Kyung-Sun Kang GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging Experimental and Molecular Medicine |
author_facet |
Jin Young Lee Kyung-Rok Yu Byung-Chul Lee Insung Kang Jae-Jun Kim Eui-Jung Jung Hyung-Sik Kim Yoojin Seo Soon Won Choi Kyung-Sun Kang |
author_sort |
Jin Young Lee |
title |
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging |
title_short |
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging |
title_full |
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging |
title_fullStr |
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging |
title_full_unstemmed |
GATA4-dependent regulation of the secretory phenotype via MCP-1 underlies lamin A-mediated human mesenchymal stem cell aging |
title_sort |
gata4-dependent regulation of the secretory phenotype via mcp-1 underlies lamin a-mediated human mesenchymal stem cell aging |
publisher |
Nature Publishing Group |
series |
Experimental and Molecular Medicine |
issn |
1226-3613 2092-6413 |
publishDate |
2018-05-01 |
description |
Aging: Clues in nuclear proteins Abnormal versions of proteins that support the structure and function of the membrane of the cell nucleus are implicated in premature aging disorders, and also in normal aging. Researchers in South Korea led by Kyung-Sun Kang at Seoul National University investigated the protein network known as the nuclear lamina. They studied a specific type of human stem cell that gives rise to bone, cartilage, muscle and fat. They found that altering the levels of proteins produced by specific key genes promotes cell aging, and the alterations led to abnormalities in the proteins of the nuclear lamina. The researchers suggest that their work provides new insights into the molecular and cellular causes of premature and normal aging. Understanding the molecular triggers of aging could lead to treatments to delay both its normal and disease-linked forms. |
url |
https://doi.org/10.1038/s12276-018-0092-3 |
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