| Summary: | The neutrophil-to-lymphocyte ratio has
emerged as a predictor of functional outcome in stroke patients. However, less is
known about the value of neutrophil to lymphocyte ratio in older patients.
This clinical study evaluated whether the
neutrophil-to-lymphocyte ratio is associated with stroke severity and early
clinical outcomes in older patients with acute ischemic stroke. This
observational study included acute ischemic stroke patients aged 80 years or
older. The patients were divided into three groups, and information was
collected, including demographic, clinical and laboratory data. The neutrophil
associations to lymphocyte ratio with stroke severity and early clinical outcomes
were assessed with logistic regression. Overall, 356 older patients were enrolled
in this study, with a median age of 85.0 (82.0–88.0). Split by tertiles of
neutrophil-to-lymphocyte ratio, 118 patients were in the bottom tertile (<2.17), 118 patients were in the middle tertile (2.17–3.36), and 120 patients were
in the top tertile (>3.36). After multivariable analysis, patients in the
highest tertile were likely to have moderate to severe stroke on admission (OR
4.87, 95% CI, 1.93–12.30, P = 0.001), higher risks of primary
unfavorable outcome (OR 2.70, 95% CI, 1.09–6.69, P = 0.032) and
secondary unfavorable outcome (OR 2.00, 95% CI, 1.00–4.00, P = 0.050)
compared to the lowest tertile. Our finding demonstrated that the
neutrophil-to-lymphocyte ratio is an independent predictor of stroke severity and
early clinical outcomes in older patients with acute ischemic stroke.
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