Optimization of [C]Raclopride Positron Emission Tomographic Rat Studies: Comparison of Methods for Image Quantification
The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [ 11 C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hindawi - SAGE Publishing
2013-06-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.2310/7290.2012.00040 |
| Summary: | The goal of this study was to compare different quantification approaches and reconstruction methods to estimate the binding potential in [ 11 C]raclopride studies in rats. The final aim was to determine if the results obtained with short-acquisition scanning were comparable to the results obtained with long-acquistion (conventional) scanning. We analyzed two rat data sets: a baseline versus a pretreatment study (with cold raclopride) and a young versus an old animal group comparison. The study results support the contention that optimization of [ 11 C]raclopride positron emission tomographic studies in rats by shortening the acquisition time is feasible. In addition, filtered backprojection is recommended as a reconstruction algorithm, although iterative methods may be more sensitive to detect within-group differences. |
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| ISSN: | 1536-0121 |