The class I myosin MYO1D binds to lipid and protects against colitis

The class I myosin MYO1D binds to lipid and protects against colitis

Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validat...

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Main Authors: William McAlpine, Kuan-wen Wang, Jin Huk Choi, Miguel San Miguel, Sarah Grace McAlpine, Jamie Russell, Sara Ludwig, Xiaohong Li, Miao Tang, Xiaoming Zhan, Mihwa Choi, Tao Wang, Chun Hui Bu, Anne R. Murray, Eva Marie Y. Moresco, Emre E. Turer, Bruce Beutler
Format: Article
Language:English
Published: The Company of Biologists 2018-09-01
Series:Disease Models & Mechanisms
Subjects:
Dextran sodium sulfate
N-ethyl-N-nitrosourea
Inflammatory bowel disease
Online Access:http://dmm.biologists.org/content/11/9/dmm035923
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spelling doaj-e7d13b984c284195b19b267544941ddb2020-11-25T01:23:34ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112018-09-0111910.1242/dmm.035923035923The class I myosin MYO1D binds to lipid and protects against colitisWilliam McAlpine0Kuan-wen Wang1Jin Huk Choi2Miguel San Miguel3Sarah Grace McAlpine4Jamie Russell5Sara Ludwig6Xiaohong Li7Miao Tang8Xiaoming Zhan9Mihwa Choi10Tao Wang11Chun Hui Bu12Anne R. Murray13Eva Marie Y. Moresco14Emre E. Turer15Bruce Beutler16 Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Department of Internal Medicine, Division of Gastroenterology, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505 USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Center for the Genetics of Host Defense, University of Texas Southwestern Medical Center, Dallas, TX 75390-8505, USA Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis. MYO1D is produced in the intestinal epithelium, and the colitis phenotype is dependent on the nonhematopoietic compartment of the mouse. Moreover, MYO1D appears to couple cytoskeletal elements to lipid in an ATP-dependent manner. These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis.http://dmm.biologists.org/content/11/9/dmm035923Dextran sodium sulfateN-ethyl-N-nitrosoureaInflammatory bowel disease
collection DOAJ
language English
format Article
sources DOAJ
author William McAlpine
Kuan-wen Wang
Jin Huk Choi
Miguel San Miguel
Sarah Grace McAlpine
Jamie Russell
Sara Ludwig
Xiaohong Li
Miao Tang
Xiaoming Zhan
Mihwa Choi
Tao Wang
Chun Hui Bu
Anne R. Murray
Eva Marie Y. Moresco
Emre E. Turer
Bruce Beutler
spellingShingle William McAlpine
Kuan-wen Wang
Jin Huk Choi
Miguel San Miguel
Sarah Grace McAlpine
Jamie Russell
Sara Ludwig
Xiaohong Li
Miao Tang
Xiaoming Zhan
Mihwa Choi
Tao Wang
Chun Hui Bu
Anne R. Murray
Eva Marie Y. Moresco
Emre E. Turer
Bruce Beutler
The class I myosin MYO1D binds to lipid and protects against colitis
Disease Models & Mechanisms
Dextran sodium sulfate
N-ethyl-N-nitrosourea
Inflammatory bowel disease
author_facet William McAlpine
Kuan-wen Wang
Jin Huk Choi
Miguel San Miguel
Sarah Grace McAlpine
Jamie Russell
Sara Ludwig
Xiaohong Li
Miao Tang
Xiaoming Zhan
Mihwa Choi
Tao Wang
Chun Hui Bu
Anne R. Murray
Eva Marie Y. Moresco
Emre E. Turer
Bruce Beutler
author_sort William McAlpine
title The class I myosin MYO1D binds to lipid and protects against colitis
title_short The class I myosin MYO1D binds to lipid and protects against colitis
title_full The class I myosin MYO1D binds to lipid and protects against colitis
title_fullStr The class I myosin MYO1D binds to lipid and protects against colitis
title_full_unstemmed The class I myosin MYO1D binds to lipid and protects against colitis
title_sort class i myosin myo1d binds to lipid and protects against colitis
publisher The Company of Biologists
series Disease Models & Mechanisms
issn 1754-8403
1754-8411
publishDate 2018-09-01
description Myosin ID (MYO1D) is a member of the class I myosin family. We screened 48,649 third generation (G3) germline mutant mice derived from N-ethyl-N-nitrosourea-mutagenized grandsires for intestinal homeostasis abnormalities after oral administration of dextran sodium sulfate (DSS). We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis. MYO1D is produced in the intestinal epithelium, and the colitis phenotype is dependent on the nonhematopoietic compartment of the mouse. Moreover, MYO1D appears to couple cytoskeletal elements to lipid in an ATP-dependent manner. These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis.
topic Dextran sodium sulfate
N-ethyl-N-nitrosourea
Inflammatory bowel disease
url http://dmm.biologists.org/content/11/9/dmm035923
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