Effect of PAS triple therapy on nerve injury, oxidative stress and inflammatory response in patients with cerebral infarction

• Main Author: Li-Jun Deng
• Format: Article
• Language: English
• Published: Editorial Board of Journal of Hainan Medical University 2017-10-01
• Series: Journal of Hainan Medical University
• Subjects: Acute cerebral infarction; Probucol; Oxidative stress response; Inflammatory response
• Online Access: http://www.hnykdxxb.com/PDF/201720/29.pdf
• ISSN: 1007-1237; 1007-1237

Objective: To study the effect of probucol + aspirin + atorvastatin (PAS) triple therapy on nerve injury, oxidative stress and inflammatory response in patients with cerebral infarction. Methods: Patients with acute cerebral infarction who were treated in Affiliated Hospital of Jianghan University between February 2015 and January 2015 were selected and randomly divided into the PAS group who received probucol + aspirin + atorvastatin triple therapy and the control group who received aspirin + atorvastatin double therapy. The markers of nerve injury, oxidative stress and inflammatory response were determined before treatment and 15 d after treatment. Results: 15 d after treatment, peripheral blood Keap-1 expression and serum GPX1 contents of both groups of patients were significantly higher than those before treatment while peripheral blood Nrf-2 and ARE expression as well as serum S100B, NSE, sTRAIL, FKN, HMGB-1, sICAM-1, Chemerin and 8-iso-PGF2α contents were significantly lower than those before treatment, and peripheral blood Keap-1 expression and serum GPX1 content of PAS group were significantly higher than those of control group while peripheral blood Nrf-2 and ARE expression as well as serum S100B, NSE, sTRAIL, FKN, HMGB-1, sICAM-1, Chemerin and 8-iso-PGF2α contents were significantly lower than those of control group. Conclusion: PAS triple therapy can reduce the nerve injury as well as oxidative stress response and inflammatory response in patients with cerebral infarction.