Efficacy and Safety of Tumor Treating Fields (TTFields) in Elderly Patients with Newly Diagnosed Glioblastoma: Subgroup Analysis of the Phase 3 EF-14 Clinical Trial

Efficacy and Safety of Tumor Treating Fields (TTFields) in Elderly Patients with Newly Diagnosed Glioblastoma: Subgroup Analysis of the Phase 3 EF-14 Clinical Trial

BackgroundUnderstudied elderly patients comprise a large segment of high-risk patients with glioblastoma (GBM) that are challenging to treat. Tumor Treating Fields (TTFields) is a locoregional, noninvasive, antimitotic therapy delivering low-intensity, intermediate-frequency alternating electric fie...

Full description

Bibliographic Details
Main Authors:	Zvi Ram, Chae-Yong Kim, Andreas F. Hottinger, Ahmed Idbaih, Garth Nicholas, Jay-Jiguang Zhu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-09-01
Series:	Frontiers in Oncology
Subjects:	elderly patients newly diagnosed glioblastoma TTFields Tumor Treating Fields phase 3 clinical trial efficacy and safety
Online Access:	https://www.frontiersin.org/articles/10.3389/fonc.2021.671972/full

Similar Items

Combined radiotherapy and concurrent tumor treating fields (TTFields) for glioblastoma: Dosimetric consequences on non-coplanar IMRT as initial results from a phase I trial
by: N. Guberina, et al.
Published: (2020-04-01)

The prognosis for patients with newly diagnosed glioblastoma receiving bevacizumab combination therapy: a meta-analysis
by: Liao KL, et al.
Published: (2018-06-01)

Concurrent Tumor Treating Fields (TTFields) and Radiation Therapy for Newly Diagnosed Glioblastoma: A Prospective Safety and Feasibility Study
by: Felix Bokstein, et al.
Published: (2020-04-01)

Prevention and Management of Dermatologic Adverse Events Associated With Tumor Treating Fields in Patients With Glioblastoma
by: Mario E. Lacouture, et al.
Published: (2020-07-01)

In Vivo Safety of Tumor Treating Fields (TTFields) Applied to the Torso
by: Roni Blatt, et al.
Published: (2021-06-01)

Tumor treating fields (TTFields) impairs aberrant glycolysis in glioblastoma as evaluated by [18F]DASA-23, a non-invasive probe of pyruvate kinase M2 (PKM2) expression
by: Chirag B. Patel, et al.
Published: (2021-01-01)

Triple-drug Therapy With Bevacizumab, Irinotecan, and Temozolomide Plus Tumor Treating Fields for Recurrent Glioblastoma: A Retrospective Study
by: Guangrong Lu, et al.
Published: (2019-01-01)

A Nomogram Predicts Individual Prognosis in Patients With Newly Diagnosed Glioblastoma by Integrating the Extent of Resection of Non-Enhancing Tumors
by: Zhe Zhang, et al.
Published: (2020-12-01)

Glioblastoma: Emerging Treatments and Novel Trial Designs
by: Vincenzo Di Nunno, et al.
Published: (2021-07-01)

Tumor-Treating Fields Therapy for Pediatric Brain Tumors
by: Atsushi Makimoto, et al.
Published: (2021-04-01)

A Comparison Between Chemo-Radiotherapy Combined With Immunotherapy and Chemo-Radiotherapy Alone for the Treatment of Newly Diagnosed Glioblastoma: A Systematic Review and Meta-Analysis
by: Montserrat Lara-Velazquez, et al.
Published: (2021-05-01)

An Overview of Sub-Cellular Mechanisms Involved in the Action of TTFields
by: Jack A. Tuszynski, et al.
Published: (2016-11-01)

Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility – a prospective, translational study
by: Dorte S. Nørøxe, et al.
Published: (2020-11-01)

Neuroimaging in Newly Diagnosed Epilepsy
by: J Gordon Millichap
Published: (2000-09-01)

Treatment with Tumor-Treating Fields Therapy and Pulse Dose Bevacizumab in Patients with Bevacizumab-Refractory Recurrent Glioblastoma: A Case Series
by: George Ansstas, et al.
Published: (2016-01-01)

Patient Reported Outcome (PRO) Among High-Grade Glioma Patients Receiving TTFields Treatment: A Two Center Observational Study
by: Julia Onken, et al.
Published: (2019-10-01)

Case Report of Complete Radiological Response of a Thalamic Glioblastoma After Treatment With Proton Therapy Followed by Temozolomide and Tumor-Treating Fields
by: Marco Stein, et al.
Published: (2020-04-01)

Role of 11C Methionine Positron Emission Tomography (11CMETPET) for Surgery and Radiation Therapy Planning in Newly Diagnosed Glioblastoma Patients Enrolled into a Phase II Clinical Study
by: Federico Pessina, et al.
Published: (2021-05-01)

Tumor treating fields (TTFields) delay DNA damage repair following radiation treatment of glioma cells
by: Moshe Giladi, et al.
Published: (2017-12-01)

Tests of Attention in Newly Diagnosed Idiopathic Epilepsy
by: J Gordon Millichap
Published: (2002-04-01)

Anxiety and Depression in Newly Diagnosed Epilepsy: A Matter of Psychological History?
by: Natacha Forthoffer, et al.
Published: (2021-10-01)

Demographic, Clinical and Management Characteristics of Newly Diagnosed COPD Patients in Turkey: A Real-Life Study
by: Suerdem M, et al.
Published: (2020-02-01)

Efficacy and safety of bortezomib with dexamethasone regimen in elderly newly diagnosed multiple myeloma patients with co-morbidities
by: Lee, Saem
Published: (2016)

Indicators of distress in newly diagnosed breast cancer patients
by: Andrea Chirico, et al.
Published: (2015-07-01)

Lenalidomide Maintenance with or without Prednisone in Newly Diagnosed Myeloma Patients: A Pooled Analysis
by: Francesca Bonello, et al.
Published: (2019-11-01)

Insulin Edema in Newly Diagnosed Type 1 Diabetes Patient
by: Ayten Oğuz, et al.
Published: (2016-09-01)

Diabetes Mellitus among Newly Diagnosed Tuberculosis Patients in Tribal Odisha: An Exploratory Study
by: Magna Manjareeka, et al.
Published: (2016-10-01)

Evaluation of effectiveness of treatment paradigm for newly diagnosed type 2 diabetes patients in Chin: A nationwide prospective cohort study
by: Xiaoling Cai, et al.
Published: (2020-01-01)

High Fear of Cancer Recurrence in Chinese Newly Diagnosed Cancer Patients
by: Xian Luo, et al.
Published: (2020-06-01)

Hospital prevalence of retinopathy in patients with newly-diagnosed type 2 diabetes
by: Waseem M AL-Zamil
Published: (2017-01-01)

Prevalence of intestinal parasites in newly diagnosed HIV/AIDS patients in Ilorin, Nigeria
by: O.A. Obateru, et al.
Published: (2017-06-01)

Serum Cotinine and Passive Smoking Status Associated with Non-Smoking Newly Diagnosed Women with Breast Cancer in Malaysia
by: Zunura’in Zahali, et al.
Published: (2021-01-01)

Nerve conduction abnormalities in patients with newly diagnosed diabetes mellitus
by: Aditya Prakash Kulkarni, et al.
Published: (2018-01-01)

Stroke Severity and Outcomes in Patients With Newly Diagnosed Atrial Fibrillation
by: Kotaro Watanabe, et al.
Published: (2021-06-01)

Changes of spermatogenesis rates and pampiniform plexus draining vein among newly diagnosed varicocele patients and recurrent ones
by: N. G. Osipov, et al.
Published: (2014-12-01)

Changes of spermatogenesis rates and pampiniform plexus draining vein among newly diagnosed varicocele patients and recurrent ones
by: N. G. Osipov, et al.
Published: (2014-12-01)

Serum testosterone in males with newly diagnosed type 2 diabetes mellitus and microvascular complications
by: S. Bajaj, et al.
Published: (2016-02-01)

Frequency of increased carotid intima media thickness and its relation with vascular complication in newly diagnosed patients of type 2 diabetes: A Hospital-based study
by: Gagan Preet Singh Taneja, et al.
Published: (2018-01-01)

Tumor Treating Fields: At the Crossroads Between Physics and Biology for Cancer Treatment
by: Francesca A. Carrieri, et al.
Published: (2020-10-01)

Risky Sexual Practice, Sexually Transmitted Infection and Associated Factors Among Newly Diagnosed HIV-positive People in Northwest Ethiopia
by: Moges NA, et al.
Published: (2020-09-01)