PPARalpha deficiency in inflammatory cells suppresses tumor growth.

PPARalpha deficiency in inflammatory cells suppresses tumor growth.

Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)alpha is a central transcriptional suppressor of inflammation, and may therefore modulate tumor growth. Here we show that PPARalpha deficiency in the host leads to overt inflamm...

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Bibliographic Details
Main Authors: Arja Kaipainen, Mark W Kieran, Sui Huang, Catherine Butterfield, Diane Bielenberg, Gustavo Mostoslavsky, Richard Mulligan, Judah Folkman, Dipak Panigrahy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC1800345?pdf=render

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