Highly prevalent Russian HIV-1 V3-loop sequence variants are susceptible to maraviroc

Highly prevalent Russian HIV-1 V3-loop sequence variants are susceptible to maraviroc

Introduction Maraviroc inhibits CCR5-tropic HIV-1 across different subtypes in vitro and has demonstrated efficacy in clinical trials. V3-loop amino acid variants observed in individual maraviroc-resistant viruses have not been found to be predictive of reduced susceptibility. Sequence-database sear...

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Bibliographic Details
Main Authors: ME Lewis, B Jubb, P Simpson, A Lopatukhin, D Kireev, M Bobkova, C Craig, E van der Ryst, M Westby, SL Butler
Format: Article
Language:English
Published: SAGE Publishing 2021-06-01
Series:Antiviral Chemistry & Chemotherapy
Online Access:https://doi.org/10.1177/20402066211025156

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