EVALUATION OF TRANSITION EFFICACY TO ANGIOTENSINE CONVERTING ENZYME INHIBITORS IN PATIENTS WITH INSUFFICIENT BLOOD PRESSURE CONTROL. THE RESULTS FROM REGIONAL PROGRAM “SARA”

• Main Authors: S. S. Yakushin, S. V. Seleznev
• Format: Article
• Language: Russian
• Published: «FIRMA «SILICEA» LLC 2017-03-01
• Series: Российский кардиологический журнал
• Subjects: arterial hypertension; prestarium a; perindopril; efficacy
• Online Access: https://russjcardiol.elpub.ru/jour/article/view/1602
• ISSN: 1560-4071; 2618-7620

Aim. To evaluate an additional antihypertension  efficacy and tolerability of perindopril comparing to sartans in real clinical practice.Material and methods. The study had been designed, that included 208 patients. Main inculsion  criteria  was  arterial  hypertension   (AH) with insufficient  blood pressure (BP) control  on  treatment by angiotensine receptor  blocker  (ARB) as monotherapy, with 1 or 2 risk factors by SCORE system and on treatment by a free ARB combination with other drugs classes. In inclusion to program, instead of ARB perindopril (Prestarium  A) 10 mg was added  or its disperging  form 10 mg in the morning. Duration of program lasted  for 3 months.  The evaluation of BP decrease was done, as the target BP levels reach and treatment response.Results. On treatment with perindopril, in 2 weeks there was statistically significant (p<0,05)  decrease of BP, and  this positive dynamics  remained  for all follow-up period. Target BP was reached in 42,4% patients. Assessment of efficacy criteria of SARA program  revealed  in all participants  BP decrease from baseline  level, with median of systolic BP decrease as 30 [25;42] mmHg, diastolic — 20 [10;20] mmHg. Target BP was reached in 42,4%.Conclusion. Transition from non-effective  former sartans treatment to perindopril makes for successful BP control with high treatment tolerance. Such approach can be recommended for patient’s management in real clinical practice.