ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN

ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN

TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1...

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Main Authors: Evgeniya Beskhmelnitsyna, Mikhail Korokin, Tatyana Avtina, Olga Martynova, Ivan Varavin, Anton Tishin
Format: Article
Language:English
Published: Pensoft Publishers 2015-12-01
Series:Research Results in Pharmacology
Subjects:
ion channel TRP; TRPA1; pain; ketorolak
nocicepti
Online Access:https://rrpharmacology.pensoft.net/article/31022/download/pdf/
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spelling doaj-e7b4cfbfeb0a42308ce35307f6e9433f2021-05-21T15:15:37ZengPensoft PublishersResearch Results in Pharmacology2658-381X2015-12-0111202210.18413/2500-235X-2015-1-4-21-2431022ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAINEvgeniya BeskhmelnitsynaMikhail KorokinTatyana AvtinaOlga MartynovaIvan VaravinAnton TishinTRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1 in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPA1 and reduced the severity of pain and inflammation is increasing.https://rrpharmacology.pensoft.net/article/31022/download/pdf/ion channel TRP; TRPA1; pain; ketorolaknocicepti
collection DOAJ
language English
format Article
sources DOAJ
author Evgeniya Beskhmelnitsyna
Mikhail Korokin
Tatyana Avtina
Olga Martynova
Ivan Varavin
Anton Tishin
spellingShingle Evgeniya Beskhmelnitsyna
Mikhail Korokin
Tatyana Avtina
Olga Martynova
Ivan Varavin
Anton Tishin
ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
Research Results in Pharmacology
ion channel TRP; TRPA1; pain; ketorolak
nocicepti
author_facet Evgeniya Beskhmelnitsyna
Mikhail Korokin
Tatyana Avtina
Olga Martynova
Ivan Varavin
Anton Tishin
author_sort Evgeniya Beskhmelnitsyna
title ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
title_short ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
title_full ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
title_fullStr ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
title_full_unstemmed ION CHANNEL TRPA1 IS A PROMISING THERAPEUTIC TARGET FOR TREATMENT OF PAIN
title_sort ion channel trpa1 is a promising therapeutic target for treatment of pain
publisher Pensoft Publishers
series Research Results in Pharmacology
issn 2658-381X
publishDate 2015-12-01
description TRPA1 is an ankyrin receptor of TRP family. It is a non-selective, calcium-permeable cation channel that is highly expressed by a subset of small diameter sensory neurons with cell bodies in the dorsal root, trigeminal, nodose and jugular ganglia. In the last time information about the role of TRPA1 in pain and cold sensitivity, as well as in the formation and maintenance of inflammation is increasing in scientific literature. Given this information, the interest for search and study of pharmacological agents, which selectively blocked of TRPA1 and reduced the severity of pain and inflammation is increasing.
topic ion channel TRP; TRPA1; pain; ketorolak
nocicepti
url https://rrpharmacology.pensoft.net/article/31022/download/pdf/
work_keys_str_mv AT evgeniyabeskhmelnitsyna ionchanneltrpa1isapromisingtherapeutictargetfortreatmentofpain
AT mikhailkorokin ionchanneltrpa1isapromisingtherapeutictargetfortreatmentofpain
AT tatyanaavtina ionchanneltrpa1isapromisingtherapeutictargetfortreatmentofpain
AT olgamartynova ionchanneltrpa1isapromisingtherapeutictargetfortreatmentofpain
AT ivanvaravin ionchanneltrpa1isapromisingtherapeutictargetfortreatmentofpain
AT antontishin ionchanneltrpa1isapromisingtherapeutictargetfortreatmentofpain
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